BIHEL Frédéric
Academic Positions
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Research Director CNRS (centre national pour la recherche scientifique)
Since October 2020, University of Strasbourg - France -
Co-director of the team "Chemogenomic and Medicinal Chemistry" - UMR7200 - LIT
Since January 2020 -
Group leader of "Catalysis and Medicinal Chemistry" - ULR7200 - LIT
Since January 2013 -
Research Associate CNRS (centre national pour la recherche scientifique)
Since oct. 2005, University of Strasbourg - France -
Postdoctoral Fellow
2003 - 2004, UMR7081, Dr JJ Bourguignon, University of Strasbourg, France
Title: New bioactive compounds targeting GPCRs -
Postdoctoral Fellow
2002 - 2003, Harvard Medical School - BWH, Center for Neurological Diseases, Pr. M. Wolfe
Title: Design, synthèse et évaluation biologique de longs peptides hélicoïdaux comme inhibiteurs du complexe γ-secrétases impliquées dans la maladie d’Alzheimer.
Education
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Academic Habilitation - Nov 17th, 2010 - University of Strasbourg
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PhD in Organic Chemistry
1999 - 2002, University of Marseille, France, Pr. J.-L. Kraus
Title : Alzheimer's Diseas: synthesis and biological evaluation of novel non-peptidic inhibitors of the formation of the β-amyloid peptide.
Jury : Pr. B. Roques, Pr. A. Tartar, Pr. M. Delaage,, Pr. D. Olive, Pr. C. Henderson, Pr. JL Kraus
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Master in Organic Chemistry
1998 - 99, University of Marseille, France
Expertise
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Drug design and medicinal chemistry
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Solid- or liquid-phase synthesis of peptides and pseudopeptides
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Synthesis of azaheterocyclic scaffolds
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Metal-catalyzed reactions (palladium, cuivre, ruthenium, iridium, etc)
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Synthesis in micellar medium
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Photolabeling and probes (biotine, fluorescent probe, etc)
