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Chemobiology of GPCRs

Photo du groupe dirigé par D Bonnet

Scientific leaders

  • Dominique Bonnet, CNRS Research Director

Scientific objectives

Our objective is to design and provide relevant, efficient and specific molecular probes necessary to better understand Life in its complexity and to open novel therapeutic routes.

We mainly focus on an important genetic, structural and functional class of receptors: the G protein coupled receptors (GPCRs).

We work along three lines :

  • Theme 1: Molecular diversity. We develop new synthetic pathways around original drug-like scaffolds.

  • Theme 2: Chemobiology. We develop original molecular probes (agonists, antagonists, allosteric modulators, fluorescent ligands, radioactive ligands) to study Life and more specifically G protein coupled receptors.

  • Thématique 3: Therapy. 1) Cancer and inflammation. We discovered chemokine neutraligands and explore their mechanism of action and therapeutic potential.2) Love and autism. We aim at discovering ocytocin agonists and imaging probes to explore vasopressin/ocytocin roles in social attachment and autism. 3) Cardiovascular diseases. We developed stabilized peptides and small organic compounds able to modulate the activity of Apeline GPCR.

Fields of expertise

  • Methods in organic synthesis :
    Heterocyclic chemistry; peptide synthesis; solid phase chemistry

  • Chemical ligation

  • Labelled probes (fluorophores, radioelements)

  • Drug design, chemical biology, medicinal chemistry

  • G protein coupled receptors (GPCRs)