Publications

2024

Rational Design of Cyanine-Based Fluorogenic Dimers to Reduce Nonspecific Interactions with Albumin and Lipid Bilayers: Application to Highly Sensitive Imaging of GPCRs in Living Cells
Yann Berthomé, Julie Gerber, Fabien Hanser, Stéphanie Riché, Nicolas Humbert, Christel Valencia, Pascal Villa, Julie Karpenko, Océane Florès, Dominique Bonnet
Bioconjugate Chem. 2024, 35, 8, 1182–1189 https://pubs.acs.org/doi/10.1021/acs.bioconjchem.4c00147

The IMS Library: an in-House Collection Based on Chemical Diversity, Scaffold Novelty and Synthetic Accessibility
Teodora Djikic-Stojsic, Guillaume Bret, Gaëlle Blond, Nicolas Girard, Clotilde Le Guen, Claire Marsol, Martine Schmitt, Séverine Schneider, Frederic Bihel, Dominique Bonnet, Michaela Gulea, Esther Kellenberger
ChemMedChem 2024, e202400381. https://doi.org/10.1002/cmdc.202400381

Hetero-Diels-Alder and CuAAC Click Reactions for Fluorine-18 Labeling of Peptides: Automation and Comparative Study of the Two Methods
Timothé Maujean, Sridévi M Ramanoudjame, Stéphanie Riché, Clothilde Le Guen, Frédéric Boisson, Sylviane Muller, Dominique Bonnet, Mihaela Gulea, Patrice Marchand
Molecules, 2024, 29 (13), 3198. https://www.mdpi.com/1420-3049/29/13/3198

Fluorinated apelin-13 mediated neuroprotective effect in multiple sclerosis models
Dafni Birmpili, Imane Charmarké-Askar, Caroline Spenlé, Stéphanie Riché, Lucas Dinh Pham-Van, Thomas Kuntzel, Thanos Xhurxhi, Aurélien Riou, Dominique Bonnet, Dominique Bagnard
Neurobiology of Disease 2024, 198, 106552. https://doi.org/10.1016/j.nbd.2024.106552

Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live‐cell Imaging of Bioactive Peptides
Antoine Mirloup, Yann Berthomé, Stéphanie Riché, Patrick Wagner, Fabien Hanser, Arthur Laurent, Xavier Iturrioz, Catherine Llorens‐Cortes, Julie Karpenko, Dominique Bonnet
Chemistry–A European Journal 2024, 30, e202401296. https://doi.org/10.1002/chem.202401296

Acute, chronic and conditioned effects of intranasal oxytocin in the mu opioid receptor knockout mouse model of autism: social context matters
Fani Pantouli, Camille Pujol, Cécile Derieux, Mathieu Fonteneau, Lucie Pellissier, Claire Marsol, Julie Karpenko, Dominique Bonnet, Marcel Hibert, Alexis Bailey, Julie Le Merrer, Jerome AJ Becker
Neuropsychopharmacology 2024, https://doi.org/10.1038/s41386-024-01915-1

Randomized double-blind placebo-controlled cosmetic trial of a topical first-in-class Neutraligand targeting the chemokine TARC/CCL17 in mild-to-moderate atopic dermatitis
Nelly Frossard, Alexandra Coïc, Thibaut Saguet, Alain Coïc, Franck Himbert, Quoc Tuan Do, Jean-Luc Galzi, Carey Suehs, Gerald Guillaumet, Pascal Bonnet, Philippe Bernard
Int J Cosmet Sci 2024, 46(3), 468-477. https://doi: 10.1111/ics.12948

Effects of oxytocin receptor agonism on acquisition and expression of pair bonding in male prairie voles
Michael C Johnson , Jonathan A Zweig, Yangmiao Zhang, Louis Nunez, Olga P Ryabinina, Marcel Hibert, Andrey E Ryabinin
Transl. Psychiatry 2024, 14(1), 286. https://doi: 10.1038/s41398-024-02993-x

2023

Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels-Alder Cycloaddition: Application to Apelin
Maujean, T.; Wagner, P.; Valencia, C.; Riche, S.; Iturrioz, X.; Villa, P.; Girard, N.; Karpenko, J.; Gulea, M.; Bonnet, D.
Bioconjug. Chem. 2023, 34, 162-168. https://doi.org/10.1021/acs.bioconjchem.2c00500
Catalyst-free thia-Diels-Alder click reaction for the labeling of peptides for imaging applications
T. Maujean, P. Marchand, P. Wagner, S. Riche, F. Boisson, N. Girard, J. Karpenko, D. Bonnet, M. Gulea
Phosphorus, Sulfur, Silicon Relat. 2023, 198, 532-535. https://doi.org/10.1080/10426507.2023.2165659

2022

Target-Focused Library Design by Pocket-Applied Computer Vision and Fragment Deep Generative Linking
Eguida M, Schmitt-Valencia C, Hibert M, Villa P, Rognan D.
J Med Chem. 2022, 65, 13771-13783. doi: 10.1021/acs.jmedchem.2c00931
NK cells and lipoxin A4 promote resolution of eosinophilic inflammation after nasal allergen challenge
Anh Poirot , Guillaume Wacht , Christine Lehalle, Philippe Saas , Nelly Frossard, Bernard Geny , Fréderic de Blay , Cindy Barnig
Allergy 2022, 77, 309-313. doi: 10.1111/all.15103
Hetero-Diels–Alder click reaction of dithioesters for a catalyst-free indirect 18F-radiolabelling of peptides
T. Maujean, P. Marchand, P. Wagner, S. Riché, F. Boisson, N. Girard, D. Bonnet* and M. Gulea*
Chem. Commun. 2022, DOI : 10.1039/D2CC04148K

Functional rescue of a nephrogenic diabetes insipidus causing mutation in the V2 Vasopressin receptor by specific antagonist and agonist pharmacochaperones
Szalai L, Sziráki A, Erdélyi LS, Kovács KB, Tóth M, Tóth AD, Turu G, Bonnet D, Mouillac B, Hunyady L, Balla A.
Front Pharmacol. 2022, 13:811836. doi: 10.3389/fphar.2022.811836

2021

Des sondes fluorogènes innovantes pour éclairer les récepteurs couplés aux protéines G
Dominique Bonnet et Andrey Klymchenko
L’actualité chimique 2021, n°468, 31-32
LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism
A. Flahault, M. Keck, P-E Girault-Sotias, L. Esteoulle, N. De Mota, D. Bonnet, C. Llorens-Cortes
Front Pharmacol. 2021, 12, 715095, doi: 10.3389/fphar.2021.715095
Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor
Fabien Hanser, Claire Marsol, Christel Valencia, Pascal Villa, Andrey S. Klymchenko, Dominique Bonnet*, and Julie Karpenko*
ACS Chem. Biol. (2021) https://pubs.acs.org/doi/10.1021/acschembio.0c00897
A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
Adrien Flahault, Pierre-Emmanuel Girault-Sotias, Mathilde Keck, Rodrigo Alvear-Perez, Nadia De Mota, Lucie Estéoulle, Sridévi M. Ramanoudjame, Xavier Iturrioz, Dominique Bonnet*, Catherine Llorens-Cortes*
NatCommun (2020) https://doi.org/10.1038/s41467-020-20560-y

2020

Endocyclic Enamides Derived from Aza-Diketopiperazines as Olefin Partners in Povarov Reaction: An Access to Tetracyclic N-Heterocycles
Timothé Maujean, Isabelle Chataigner, Nicolas Girard, Mihaela Gulea* and Dominique Bonnet*
EurJOC (2020) https://doi.org/10.1002/ejoc.202001339
Three cheers for nitrogen: aza-DKPs, the aza analogues of 2,5-diketopiperazines
Timothe Maujean, Nicolas Girard, A. Ganesan, Mihaela Gulea* and Dominique Bonnet*
RSC Advances (2020) https://doi.org/10.1039/d0ra09457a
Self-organization properties of a GPCR binding peptide incorporating fluorinated tail studied by fluorine NMR.
Jourdain de Muizo C., Ramanoudjame S.M, Esteoulle L., Ling C., Brou G., Anton N., Vandamme T., Delsuc M-A., Bonnet D., Kieffer B.
ChemBioChem, 2020, https://doi.org/10.1002/cbic.202000601
Première cartographie par fluorescence des récepteurs couplés aux protéines G
Klymchenko A.S. et Bonnet, D.
Communication CNRS, « En direct des laboratoires de l'Institut de Chimie » 2020

A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice
Lucie Esteoulle; François Daubeuf; Mayeul Collot; Stéphanie Riché; Thierry Durroux; David Brasse; Patrice Marchand; Iuliia A. Karpenko; Andrey S. Klymchenko; Dominique Bonnet
Chemical Science 2020; DOI: 10.1039/D0SC01018A
Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.
Fellous TG, Redpath AN, Fleischer MM, Gandhi S, Hartner SE, Newton MD, François M, Wong SP, Gowers KHC, Fahs AM, Possley DR, Bonnet D, Urquhart P, Nicolaou A, Baker KC, Rankin SM.
NPJ Regen Med. 2020 Feb 21;5:3. doi: 10.1038/s41536-020-0088-1. eCollection 2020.
Neutralization of CXCL12 attenuates established pulmonary hypertension in rats.
Bordenave J, Thuillet R, Tu L, Phan C, Cumont A, Marsol C, Huertas A, Savale L, Hibert M, Galzi JL, Bonnet D, Humbert M, Frossard N, Guignabert C.
Cardiovasc Res. 2020 Mar 1;116(3):686-697. doi: 10.1093/cvr/cvz153
A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain.
Hilfiger L, Zhao Q, Kerspern D, Inquimbert P, Andry V, Goumon Y, Darbon P, Hibert M, Charlet A.
Sci Rep. 2020 Feb 20;10(1):3017. doi: 10.1038/s41598-020-59929-w.

2019

Chemoselective Acylation of Hydrazinopeptides to Access Fluorescent Probes for Time-Resolved FRET Assays on GPCRs.
Ramanoudjame S.M.; Esteoulle L.; Riché S.; Margathe J.F.; Durroux T.; Karpenko I.A.; Bonnet D.
Methods Mol Biol. 2019; 1947:137-147. doi: 10.1007/978-1-4939-9121-1_7. Walker J.M., Series Editor; Tiberi M. Editor; G Protein-Coupled Receptor Signaling Methods and Protocols
Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology
Heuninck J.; Hounsou C.; Dupuis E.; Trinquet E.; Mouillac B.; Pin J.P.; Bonnet D.; Durroux T.
Methods Mol Biol. 2019; 1947:151-168. doi: 10.1007/978-1-4939-9121-1_8. Walker J.M., Series Editor; Tiberi M. Editor; G Protein-Coupled Receptor Signaling Methods and Protocols
A l’ombre d’Eros: une chimie de l’Amour ?
Marcel Hibert et Dominique Bonnet
L’actualité chimique, 2019, n°444-445, 61-67

2018

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia
Regenass, P.; Abboud, D.; Daubeuf, F; Lehalle, C; Gizzi, P; Riche, S; Hachet-Haas, M ; Rohmer, F; Gasparik, V; Boeglin, D; Haiech, J; Knehans, T; Rognan, D; Heissler, D; Marsol, C; Villa, P; Galzi, JL; Hibert, M; Frossard, N; Bonnet, D.
J. Med. Chem., 2018, 61, 7671-7686
« Highlight » sur le site CNRS : un « neutraligand » pour combattre les maladies inflammatoires
Bonnet, D.
En direct des laboratoires de l'Institut de Chimie, 2018
http://www.cnrs.fr/inc/communication/direct_labos/bonnet4.htm
LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism
Frantz, M.C.; Pellissier, L.P.; Pflimlin, E.; Loison, S.; Gandia, J.; Marsol, C.; Durroux, T.; Mouillac, B.; Becker, J.A.J.; Le Merrer, J; Valencia, C.; Villa, P.; Bonnet, D.; Hibert, M.
J. Med. Chem., 2018, 61, 8670-8692
Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines
Péron, F.; Riché, S.; Lesur, B.; Hibert, M.; Breton, P.; Fourquez, J.-M.; Girard, N.; Bonnet, D.
ACS Omega, 2018, 3 (11), pp 15182–15192
From the Promiscuous Asenapine to Potent Fluorescent Ligands Acting at a Series of Aminergic G-Protein-Coupled Receptors
Hounsou, C.; Baehr, C.; Gasparik, V.; Alili, D.; Belhocine, A.; Rodriguez, T.; Dupuis, E.; Roux, T.; Mann, A.; Heissler, D.; Pin, J.P.; Durroux, T.; Bonnet, D.; Hibert, M.
J. Med. Chem., 2018, 1, 174-188

2017

Decreased Migration of Dendritic Cells into the Jugular-Nodose Ganglia by the CXCL12 Neutraligand Chalcone 4 in Ovalbumin-Sensitized Asthmatic Mice
Heck, S.; Daubeuf, F.; Le, D.D.; Sester, M.; Bonnet, D.; Bals, R.; Frossard, N.; Dinh, Q.T.
Neuroimmunomodulation, 2017, 24, 331-340
Two distinct CXCR4 antagonists mobilise progenitor cells in mice by different mechanisms
Redpath, N.A.; Francois, M.; Wong, S.-P.; Bonnet, D.; Rankin, M.S.
Blood Advances, 2017, 22, 1934-1943.
Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines
Regenass, P.; Bosc, D.; Riche, S.; Gizzi, P.; Hibert, M.; Karmazin, L.; Ganesan, A.; Bonnet, D.
J. Org. Chem., 2017, 82, 3239-3244
A time-resolved FRET cell-based binding assay for the apelin receptor
Valencia, C; Dujet, C; Margathe, JF; Iturrioz, X; Roux, T; Trinquet, E; Villa, P; Hibert, M; Dupuis, E; Llorens-Cortes, C; Bonnet, D.
Chem. Med. Chem., 2017, 12, 925-931.
Development of original metabolically-stable apelin-17 analogs with diuretic and cardiovascular effects
Gerbier, R.; Alvear-Perez,R.; Margathe, J.F.; Flahault, A.; Couvineau, P.; Gao, J.; De Mota, N.; Dabire, H.; Li, B.; Ceraudo, E.; Hus-Citharel, A.; Esteoulle, L.; Bisoo, C.; Hibert, M.; Berdeaux, A.; Iturrioz, X.; Bonnet, D.; Llorens-Cortes, C.
FASEB J., 2017, 31, 687-700

2016

Development of original metabolically-stable apelin-17 analogs with diuretic and cardiovascular effects.
Gerbier, R.; Alvear-Perez,R.; Margathe, J.F.; Flahault, A.; Couvineau, P.; Gao, J.; De Mota, N.; Dabire, H.; Li, B.; Ceraudo, E.; Hus-Citharel, A.; Esteoulle, L.; Bisoo, C.; Hibert, M.; Berdeaux, A.; Iturrioz, X.; Bonnet, D.; Llorens-Cortes, C.
FASEB J, 2016, doi:10.1096/fj.201600784R.
A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis
Regenass, P.; Riche, S.; Peron, F.; Rognan, D.;Hibert, M.;Girard, N. and Bonnet, D.
Org Biomol Chem, 2016, 14, 8859-8863
Convenient access to fluorescent probes by chemoselective acylation of hydrazinopeptides: Application to the synthesis of the first far-red ligand for Apelin receptor imaging
Margathe, J.F.; Iturrioz, X.;Regenass, P.; Karpenko, I.A.;Humbert, N.;De Rocquigny, H.; Hibert, M.;Llorens-Cortes, C.; Bonnet, D.
Chem Eur J, 2016, 22, 1399-1405
Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions
Karpenko, I. A.;Niko, Y.;Yakubovskyi, V. P.;Gerasov, A. O.;Bonnet, D.;Kovtun, Y. P. and Klymchenko, A. S.
J Mater Chem C, 2016, 4, 3002-3009

2015

New fluorescein precursors for live bacteria detection.
Guilini, C.; Baehr, C.; Schaeffer, E.; Gizzi, P.; Rufi, F.; Haiech, J.; Weiss, E.; Bonnet, D.; Galzi J.L.
Anal Chem. 2015, 87, 8858-8866

Convenient access to fluorescent probes by chemoselective acylation of hydrazinopeptides: Application to the synthesis of the first far-red ligand for Apelin receptor imaging
Margathe, J.F.; Iturrioz, X.;Regenass, P.; Karpenko, I.A.;Humbert, N.;De Rocquigny, H.; Hibert, M.;Llorens-Cortes, C.; Bonnet, D.
Chem Eur J, 2015, DOI: chem.201503630.

Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions
Karpenko, I.A.; Niko, Y.; Gerasov, A.O.; Yakubovskyi, V.P.; Bonnet, D.; Kovtun Y.P., Klymchenko, A.S.
J Mater Chem, 2015, DOI: 10.1039/C5TC03411

Selective Non-Peptidic Fluorescent Ligands for Oxytocin Receptor: Design, Synthesis and Application to Time-Resolved FRET Binding Assay
Karpenko, I.A.; Margathe, J.-F.; Rodriguez, T.; Hibert, M.; Durroux,T.; Bonnet, D.
J Med Chem, 2015, 58, 2547-2552

Squaraine as bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging
Karpenko, I.A.; Klymchenko A. S.; Gioria, S.; Kreder, R.; Shulov, I.; Villa, P.; Mély, Y.; Hibert, M.; Bonnet, D.
Chem Commun, 2015, 51, 2960-2963

A strategy to discover decoy chemokine ligands with an anti-inflammatory activity
Abboud, D.; Daubeuf, F.; Do, Q.T.; Utard, V; Villa, P.; Haiech, J.; Bonnet, D; Hibert, M.; Bernard, P.; Galzi, J.L.; Frossard, N.
Scientific Reports, 2015, 5, 14746, DOI: 10.1038/srep14746

Increasing cellular immunogenicity to peptide-based vaccine candidates using a
fluorocarbon antigen delivery system
Francis, J.N; Thaburet, J-F.; Bonnet, D.; Sizer, P.J.; Brown, C.B.; Georges, B.
Vaccine, 2015, 33, 1071-1076

Time-Resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer.
Hounsou, C.; Margathe, J. F.; Oueslati, N.; Belhocine, A.; Dupuis, E.; Thomas, C.; Mann, A.; Ilien, B.; Rognan, D.; Trinquet, E.; Hibert, M.; Pin, J. P.; Bonnet, D. and Durroux. T.
ACS ChemBiol, 2015, 10, 466-474

« Highlight » sur le site CNRS: Un essai innovant basé sur la fluorescence pour étudier la pharmacologie des complexes de récepteurs couplés aux protéines G; Bonnet, D. et Durroux, T.; http://www.cnrs.fr/inc/communication/direct_labos/bonnet2.htm

Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging
Karpenko, I.A.; Collot, M.; Richert, L.; Valencia, C.; Villa, P.; Mély, Y.; Hibert, M.; Bonnet, D. and Klymchenko A. S.
J Am Chem Soc, 2015, 137, 405-412.

Fluorogenic dye tweezers coax cells to glow red
Karpenko, I.A.; Collot, M.; Richert, L.; Valencia, C.; Villa, P.; Mély, Y.; Hibert, M.; Bonnet, D. and Klymchenko A. S.
J Am Chem Soc Spotlights 2015, 137, 1-1

2014

Time-Resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer.
Hounsou, C.;Margathe, J. F.;Oueslati, N.;Belhocine, A.;Dupuis, E.;Thomas, C.;Mann, A.;Ilien, B.;Rognan, D.;Trinquet, E.;Hibert, M.;Pin, J. P.;Bonnet, D. and Durroux, T.
ACS ChemBiol. 2014, DOI: 10.1021/cb5007568,
Quantitative Structure-Property Relationship Modeling: A Valuable Support in High-Throughput Screening Quality Control
Ruggiu, F.;Gizzi, P.;Galzi, J. L.;Hibert, M.;Haiech, J.;Baskin, I.;Horvath, D.;Marcou, G. and Varnek, A.
Analytical Chemistry 2014, 86, 2510-2520
Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process
Regenass, P.;Margathe, J. F.;Mann, A.;Suffert, J.;Hibert, M.;Girard, N. and Bonnet, D.
Chemical Communications 2014, 50, 9657-9660
Structure Activity Relationship Studies toward the Discovery of Selective Apelin Receptor Agonists
Margathe, J. F.;Iturrioz, X.;Alvear-Perez, R.;Marsol, C.;Riche, S.;Chabane, H.;Tounsi, N.;Kuhry, M.;Heissler, D.;Hibert, M.;Llorens-Cortes, C. and Bonnet, D.
Journal of Medicinal Chemistry 2014, 57, 2908-2919
Coordination Cluster Analogues of the High-Spin [Mn-19] System with Functionalized 2,6-Bis(hydroxymethyl)phenol Ligands
Mameri, S.;Ako, A. M.;Yesil, F.;Hibert, M.;Lan, Y. H.;Anson, C. E. and Powell, A. K.
European Journal of Inorganic Chemistry 2014, 4326-4334
Red Fluorescent Turn-On Ligands for Imaging and Quantifying G Protein-Coupled Receptors in Living Cells
Karpenko, I. A.;Kreder, R.;Valencia, C.;Villa, P.;Mendre, C.;Mouillac, B.;Mely, Y.;Hibert, M.;Bonnet, D. and Klymchenko, A. S.
Chembiochem 2014, 15, 359-363
Design of a General-Purpose European Compound Screening Library for EU-OPENSCREEN
Horvath, D.;Lisurek, M.;Rupp, B.;Kuhne, R.;Specker, E.;von Kries, J.;Rognan, D.;Andersson, C. D.;Almqvist, F.;Elofsson, M.;Enqvist, P. A.;Gustavsson, A. L.;Remez, N.;Mestres, J.;Marcou, G.;Varnek, A.;Hibert, M.;Quintana, J. and Frank, R.
Chemmedchem 2014, 9, 2309-2326

2013

Exploration of the Orthosteric/Allosteric Interface in Human M1 Muscarinic Receptors by Bitopic Fluorescent Ligands
Daval, S. B.;Kellenberger, E.;Bonnet, D.;Utard, V.;Galzi, J. L. and Ilien, B.
Molecular Pharmacology 2013, 84, 71-85
An Antedrug of the CXCL12 Neutraligand Blocks Experimental Allergic Asthma without Systemic Effect in Mice
Daubeuf, F.;Hachet-Haas, M.;Gizzi, P.;Gasparik, V.;Bonnet, D.;Utard, V.;Hibert, M.;Frossard, N. and Galzi, J. L.
Journal of Biological Chemistry 2013, 288, 11865-11876

2012

Use of an alpha 5 beta 1 Small Non-peptidic Antagonist to Inhibit Glioblastoma Migration Fostered by Integrin Expression
Ray, A.;Janouskova, H.;Lehmann, M.;Bonnet, D.;Villa, P.;Brino, L.;Martin, S.;Rebel, I. L.;Rognan, D. and Dontenwill, M.
European Journal of Cancer 2012, 48, S244-S244
Selective Fluorescent Nonpeptidic Antagonists For Vasopressin V-2 GPCR: Application To Ligand Screening and Oligomerization Assays
Loison, S.;Cottet, M.;Orcel, H.;Adihou, H.;Rahmeh, R.;Lamarque, L.;Trinquet, E.;Kellenberger, E.;Hibert, M.;Durroux, T.;Mouillac, B. and Bonnet, D.
Journal of Medicinal Chemistry 2012, 55, 8588-8602
Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo
Gasparik, V.;Daubeuf, F.;Hachet-Haas, M.;Rohmer, F.;Gizzi, P.;Haiech, J.;Galzi, J. L.;Hibert, M.;Bonnet, D. and Frossard, N.
Acs Medicinal Chemistry Letters 2012, 3, 10-14
Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors
Daval, S. B.;Valant, C.;Bonnet, D.;Kellenberger, E.;Hibert, M.;Galzi, J. L. and Ilien, B.
Journal of Medicinal Chemistry 2012, 55, 2125-2143
Involvement of the TGF beta pathway in the regulation of alpha(5)beta(1) integrins by caveolin-1 in human glioblastoma
Cosset, E. C.;Godet, J.;Entz-Werle, N.;Guerin, E.;Guenot, D.;Froelich, S.;Bonnet, D.;Pinel, S.;Plenat, F.;Chastagner, P.;Dontenwill, M. and Martin, S.
International Journal of Cancer 2012, 131, 601-611
Combinatorial Aid for Underprivileged Scaffolds: Solution and Solid-phase Strategies for a Rapid and Efficient Access To Novel Aza-diketopiperazines (Aza-DKP)
Bonnet, D.;Margathe, J. F.;Radford, S.;Pflimlin, E.;Riche, S.;Doman, P.;Hibert, M. and Ganesan, A.
Acs Combinatorial Science 2012, 14, 323-334
Adsorption of [Mn-19] Aggregates with S=83/2 onto HOPG Surfaces
Ako, A. M.;Alam, M. S.;Mameri, S.;Lan, Y. H.;Hibert, M.;Stocker, M.;Muller, P.;Anson, C. E. and Powell, A. K.
European Journal of Inorganic Chemistry 2012, 4131-4140
Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice
Balabanian, K.;Brotin, E.;Biajoux, V.;Bouchet-Delbos, L.;Lainey, E.;Fenneteau, O.;Bonnet, D.;Fiette, L.;Emilie, D. and Bachelerie, F.
Blood 2012, 119, 5722-5730