Step economy is a preeminent goal of contemporary organic synthesis. It influences the length, efficiency, cost, development time, execution time, effort, separation science, and environmental impact of a synthesis and therefore its capacity to efficaciously deliver a meaningful supply of target. Step economy is in turn influenced by reaction selection and is generally favored by the use of reactions that allow the greatest increase in target relevant complexity.

The ability to access more complex targets with step economy is thus principally determined and limited by the lexicon of known organic reactions.

The introduction of new reactions is thus a  critical, if not unique, requirement for extending the reach of contemporary synthesis and consequently its impact on fundamental and applied aspects of chemistry, biology, medicine, materials, and environmental sciences.

Prompted by the above considerations, we have focused effort on the design or discovery of novel or new reactions that provide fundamentally new ways of accessing ring systems commonly encountered in natural and designed polycyclic targets.