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  2. Synthèse Organique Métallo-induite et Hétérochimie (SOMHet)
  3. Publications

2011-2016

2016

  • Recent Contributions to Hetero Diels-Alder Reactions
    Blond G., Gulea M., Mamane V.
    Curr. Org. Chem.    , 2016, 20, 2161

  • A Step-Economical Multicomponent Synthesis of 3D-Shaped Aza-Diketopiperazines and Their Drug-like Chemical Space Analysis
    Regenass P.M., Riché S., Peron F., Rognan D., Hibert M., Girard N., Bonnet D.
    Org. Biomol. Chem.,     2016, 14, 8859-8863

  • A general and efficient synthesis of 2-pyridones, 2-quinolinones and 1-isoquinolinones from azine-N-oxides.
    Wang D., Zhao J., Wang Y., Hu J., Li L., Miao L., Feng H., Désaubry L;, Yu P.
    Asian J. Org. Chem.     2016, 5, 1442-1446

  • Molecular pathways: the eIF4F translation initiation complex –new opportunities for cancer treatment.
    Malka-Mahieu H., Newman M., Désaubry L., Robert C., Vagner S.
    Clin Cancer Res.    , 2016, 22, in press

  • Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines.
    Malka-Mahieu H., Girault I., Rubington M., Leriche M., Welsch C., Kamsu-Kom N., Zhao Q., Désaubry L., Vagner S., Robert C.
    Cell cycle    , 2016, 15, 2405-2409

  • Synthesis of hydroxybenzofurans by condensation of quinones with benzoylacetone: revised structure of the adducts.
    Hammoud H., Zhao Q., Désaubry L. 
    Tetrahedron Lett., 2016,     57, 4044–4045

  • STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A.
    Wang S, Darini C, Désaubry L, Koromilas AE.
    Mol Cancer Ther.    ,     2016,  15, 3055-3063

  • Synthesis of 3-Substituted Chromones and Quinolones from Enaminones
    Joussot J., Schoenfelder A., Larquetoux L., Nicolas M., Suffert J., Blond G.
    Synthesis, 2016, 48, 3364-3372

  • Bioisosteric modification of flavaglines
    Qian Z., Tijeras-Raballand A., de Gramont A., Raymond E., Désaubry L.
    Tetrahedron Lett.    , 2016, 57, 2943

  • Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives.
    Castanheiro T., Suffert J., Gulea M., Donnard M.
    Org. Lett., 2016, 18, 2588   (OPEN ACCESS)

  • Synthesis of Cyclooctatetraenes through a Palladium-Catalyzed Cascade Reaction.
    Blouin S., Gandon V., Blond G., Suffert J.
    Angew. Chem. Int. Ed.,     2016, 55, 7208

  • Recent Advances in the Chemistry of Organic Thiocyanates.
    Castanheiro T., Suffert J., Donnard M., Gulea M.
    Chem. Soc. Rev., 2016, 45, 494-505

  • Flavaglines ameliorate experimental colitis and protect against intestinal epithelial cell apoptosis and mitochondrial dysfunction.
    Han J., Zhao Q., Basmadjian C., Désaubry L., Theiss A.L.
    Inflamm. Bowel Dis    .     2016, 22, 55-67

  • Recent advances in the synthesis of flavaglines, a family of potent bioactive natural compounds coming from traditional Chinese medicine.
    Zhao Q., Abou-Hamdan H., Désaubry L.
    Eur. J. Org. Chem.    , 2016, 5908-5916

  • Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.
    Fleury A., Hoch L., Martinez MC, Faure H., Taddei M., Petricci E., Manetti F., Girard N., Mann A., Jacques C., Larghero J., Ruat m., Adriantsitohaina R., LeLay S.
    Scientific Reports    , 2016, 23479

 

2015

  • Discovery and cardioprotective effects of the first non-peptide agonists of the G protein-coupled prokineticin receptor-1.
    Gasser A., Brogi S., Urayama K., Nishi T., Kurose H., Tafi A., Ribeiro N., Désaubry L., Nebigil CG.
    Plos One.     2015, 10, e0121027

  • Revision of the synthesis and pharmacological activity of a reported translation inhibitor.
    Basmadjian C., Malka-Mahieu H., Désaubry L.
    Anticancer Agents Med. Chem.     2015, 15, 1305-1307
  • Flavaglines stimulate transient receptor potential melastatin type 6 (TRPM6) channel activity.
     Blanchard MG., de Baaij J.H.F., Verkaart S.A.J., Lameris A.L., Basmadjian C., Zhao Q., Désaubry L., Bindels R.J.M., Hoenderop JG.
    Plos One 2015, 10, e0119028.

     

  • MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the smoothened receptor.

    Hoch, L.; Faure, H.; Roudaut, H.; Schoenfelder, A.; Mann, A.; Girard, N.; Bihannic, L.; Ayrault, O.; Petricci, E.; Taddei, M.
    FASEB 2015, 19, 1817-1829

  • Assessment of flavaglines as potential chikungunya virus entry inhibitors.
    Wintachai, P.; Thuaud, F.; Basmadjian, C.; Ubol, S.; Désaubry, L.; Smith, D.R.
    Microbiol. Immunol. 2015, 59, 129-141

  • Exploratory studies toward a synthesis of flavaglines . A novel access to a highly substituted. cyclopentenone intermediate
    Basmadjian, C.; Zhao, Q.; Désaubry, L.
    Tetrahedron Lett.     2015, 56, 727–730.

2014

  • Practical access to aromatic thiocyanates by CuCN-mediated direct aerobic oxidative cyanation of thiophenols and diaryl disulfides.
    Castanheiro, T.;  Gulea, M.; Donnard, M.; Suffert, J.
    Eur. J. Org. Chem., 2014, 2014, 7814-7817.

  • eIF4F is a key and targetable convergence nexus of multiple resistance mechanisms to anti-RAF and anti-MEK cancer therapies.
    Boussemart, L.; Malka-Mahieu, H.; Girault, I.; Allard, D.; Hemmingsson, O.; Tomasic, G.; Thomas, M.; Basmadjian, C.; Ribeiro, N.; Thuaud, F.; Mateus, C.; Routier, E.; Kamsu-Kom, N.; Agoussi, S.; Eggermont, A. M.; Désaubry, L.; Robert, C.; Vagner, S.
    Nature 2014, 513, 105–109.

  • Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process.
    Regenass, P.; Margathe, J.-F.; Mann, A.; Suffert, J.; Hibert, M.; Girard, N.; Bonnet, D.
    Chem. Commun. 2014, 50, 9657–9660.

  • Cyclocarbopalladation/cross-coupling cascade reactions in sulfide series: access to sulfur heterocycles.
    Castanheiro, T.; Donnard, M.; Gulea, M.; Suffert, J.
    Org. Lett.     2014, 16, 3060–3063.

  • Benzofuran derivatives as anticancer inhibitors of mTOR signaling.
    Salomé, C.; Ribeiro, N.; Chavagnan, T.; Thuaud, F.; Serova, M.; de Gramont, A.; Faivre, S.; Raymond, E.; Désaubry, L.
    Eur. J. Med. Chem.     2014, 81, 181–191.

  • Cancer wars: natural products strike back.
    Basmadjian, C.; Zhao, Q.; Bentouhami, E.; Djehal, A.; Nebigil, C. G.; Johnson, R. A.; Serova, M.; de Gramont, A.; Faivre, S.; Raymond, E.; Désaubry, L. G.
    Front. Chem.     2014, 2, 20.

  • Electrochemical Access to 8-(1-Phenyl-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane-7-carbonitrile. Application to the Asymmetric Syntheses of (+)-Myrtine and Alkaloid (+)-241D.
    Vu, V. H.; Louafi, F.; Girard, N.; Marion, R.; Roisnel, T.; Dorcet, V.; Hurvois, J.-P.
    J. Org. Chem. 2014, 79, 3358–3373.

  • Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.
    Emhemmed, F.; Ali Azouaou, S.; Thuaud, F.; Schini-Kerth, V.; Désaubry, L.; Muller, C. D.; Fuhrmann, G.
    Biochem. Pharmacol. 2014, 89, 185–196.

  • Benzofuran derivatives as a novel class of inhibitors of mTOR signaling.
    Salomé, C.; Narbonne, V.; Ribeiro, N.; Thuaud, F.; Serova, M.; de Gramont, A.; Faivre, S.; Raymond, E.; Désaubry, L.
    Eur. J. Med. Chem.     2014, 74, 41–49.

  • Copper-catalyzed C-C bond formation in natural product synthesis: elegant and efficient solution to a key bond disconnection
    (book chapter)
    Nicolas Blanchard; Morgan Donnard
    chapter 18 in Copper-Mediated Cross-Coupling Reactions; Evano G.; Blanchard, N. Eds.; John Wiley & Sons: Hoboken, 2014, pp 683-723.

2013

  • N-[3a-(4-Bromophenyl)-8b-hydroxy-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b ]benzofuran-1-yl]formamide monohydrate.
    Aubert M., Thuaud F., Ribeiro N., Désaubry L., Espinosa E.
    Acta Cryst. E          2013, 69, o52-o53
  • Discovery, Molecular and Pharmacological Characterization of GSA-10, a Novel Small-Molecule Positive Modulator of Smoothened
    Tatiana Gorojankina, Lucile Hoch, Hélène Faure, Hermine Roudaut, Elisabeth Traiffort, Angèle Schoenfelder, Nicolas Girard, André Mann, Fabrizio Manetti, Antonio Solinas, Elena Petricci, Maurizio Taddei, and Martial Ruat
    Molecular Pharmacology     2013, 83, 1020-1029
  • Asymmetric Three-Component Domino Reaction: An Original Access to Chiral Nonracemic 1,3-Thiazin-2-ones
    Flavie Peudru, Fabien Le Cavelier, Jean-Francois Lohier, Mihaela Gulea and Vincent Reboul
    Org. Lett.     2013, 15, 5710-5713
    Highlighted in SYNFACTS 2014 by Victor Snieckus, Jane Panteleev (Pfizer), 0320014, 10(2), 0136
  • Ortho-(methylsulfanyl)phenylphosphonates and derivatives: Synthesis and applications as mono- or bidentate ligands for the preparation of platinum complexes
    Matthieu Hamela, Mathieu Lecinq, Mihaela Gulea, Jiří Kozelka
    J. Organomet. Chem.     2013, 745-746, 206-213
  • Expeditious cascade reactions: controlled syntheses of fenestradienes and cyclooctatrienes under palladium catalysis
    Mélanie Charpenay, Aicha Boudhar, Catherine Hulot, Gaëlle Blond, Jean Suffert 
    Tetrahedron     2013, 69, 7568-7591
    special issue in honour of Pr Paul A. Wender
  • Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential,
    Thuaud F, Ribeiro N, Nebigil CG, Désaubry L.
    Chem Biol.     2013, 20, 316-331

2012

  • Cytochromes P450 CYP94C1 and CYP94B3 catalyze two successive oxidation steps of plant hormone Jasmonoyl-isoleucine for catabolic turnover.
    Heitz, T.; Widemann, E.; Lugan, R.; Miesch, L.; Ullmann, P.; Désaubry, L.; Holder, E.; Grausem, B.; Kandel, S.; Miesch, M.; Werck-Reichhart, D.; Pinot, F.
    J. Biol. Chem.     2012, 287, 6296–6306.
  • The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2.
    Polier, G.; Neumann, J.; Thuaud, F.; Ribeiro, N.; Gelhaus, C.; Schmidt, H.; Giaisi, M.; Köhler, R.; Müller, W. W.; Proksch, P.; Leippe, M.; Janssen, O.; Désaubry, L.; Krammer, P. H.; Li-Weber, M.
    Chem. Biol.     2012, 19, 1093–1104.
  • Flavaglines as potent anticancer and cytoprotective agents.
    Ribeiro, N.; Thuaud, F.; Bernard, Y.; Gaiddon, C.; Cresteil, T.; Hild, A.; Hirsch, E. C.; Michel, P. P.; Nebigil, C. G.; Désaubry, L.
    J. Med. Chem.     2012, 55, 10064–10073.
  • Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.
    Solinas, A.; Faure, H.; Roudaut, H.; Traiffort, E.; Schoenfelder, A.; Mann, A.; Manetti, F.; Taddei, M.; Ruat, M.
    J. Med. Chem    .     2012, 55, 1559–1571.

  • Trimethoxyarene as a Highly Ionizable Tag for Reaction Analysis by Atmospheric Pressure Photoionization Mass Spectrometry (APPI/MS): Exploration of Heterocyclic Synthesis.
    Bui The Thuong, M.; Catala, C.; Colas, C.; Schaeffer, C.; Van Dorsselaer, A.; Mann, A.; Wagner, A.
    Eur. J. Org. Chem. 2012, 85–92

  • Stereoselective Multicomponent Assembly of Enantiopure Oxazolopiperidines and -azepines.
    Zill, N.; Schoenfelder, A.; Girard, N.; Taddei, M.; Mann, A.
    J. Org. Chem.     2012, 77, 2246-2253

  • Mild chemo-selective hydration of terminal alkynes catalysed by AgSbF6
    Bui The Thuong, M.; Mann, A.; Wagner, A.
    Chem. Commun. 2012, 48, 434-436

  • Search for the Most Primitive Membranes: Some Remaining Problems.
    Nakatani, Y.; Ribeiro, N.; Strieff, S.; Désaubry, L.; Ourisson, G.
    Orig. Life Evol. Biosph.     2012, 42, 497-501

2011

  • Cyclohydrocarbonylation-Based Strategy toward Poly- Substituted Piperidines.
    Arena, G.; Zill, N; Salvadori, J.; Girard, N.; Mann, A.; Taddei, M.
    Org. Lett.     2011, 13, 2294–2297

  • Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27
    Bernard, Y.; Ribeiro, N.; Thuaud, F.; Türkeri, G.; Dirr, R.; Boulberdaa, M.; Nebigil, C.G.; Désaubry, L.; Saks, V.
    PLOS     ONE     2011, 6, e25302 (2011).

  • Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice
    Cazorla, M.; Prémont, J.; MAnn, A.; Girard, N.; Kellendonk, C.; Rognan, Didier
    J. Clin. Invest. 2011, 121, 1846-1857

  • New Palladium-Catalyzed Cascades: 4-exo-dig Cyclocarbopalladation Reaction Followed by Suzuki-Miyaura or Sonogashira Cross-Coupling
    Charpenay, M.; Boudhar, A.; Siby, A.; Schigand, S.; Blond, G.; Suffert, J.
    Adv. Synth. Catal. 2011, 353, 3151-3156

  • Microwave-Assisted Domino Hydroformylation without Syngas
    Cini, E.; Airiau, E.; Girard, N.; Mann, A.; Salvadori, J.; Taddei, M.
    Synlett 2011, 199-202