Publications

publicationpublibook


2018

 

  • Synthesis of Polyheterocyclic Tropones by [2+2+2+1] Carbonylative Cycloaddition of Triynes
    Salacz L.
    , Girard N., Blond G., Suffert J.
    Org. Lett., 2018, 20, 3915-3918
  • Molecular Diversity of Cyclooctatetraenes through Palladium-Catalyzed Cascade Reactions
    Blouin S., Pertschi R., Schoenfelder A., Suffert J., Blond G.
    Adv. Synth. Catal.
    , 2018, 360, 2166-2171 (VIP)

  • Synthesis of Sulfur-Containing Exo-Bicyclic Dienes and Their Diels–Alder Reactions To Access Thiacycle-Fused Polycyclic Systems
    Castanheiro T., Schoenfelder A., Donnard M., Chataigner I., Gulea M.
    J. Org. Chem.,
    2018, 83, 4505-4515

2017

  • Pd and Cu-mediated domino reactions for the synthesis of sulfur heterocycles.
    Donnard M., Castanheiro T., Gulea M.
    in Targets in Heterocyclic Systems (book chapter), vol. ed. Orazio Attanassi, Perdo Merino et Domenico Spinelli, Societa Chimica Italiana, 2017, vol. 21, 255-276
  • Synthesis of Benzo[c]silole derivatives Bearing a Tetrasubstituted Exocyclic C=C Double Bond by Palladium-Catalyzed Domino Reactions.
    Wagner P., Gulea M., Suffert J., Donnard M.
    Chem. Eur. J.
    ,
    2017, 23, 7458-7462

  • Intramolecular inverse electron-demand [4+2] cycloadditions of ynamidyl-tethered pyrimidines: comparative studies in trifluorotoluene and sulfolane
    Donnard M., Duret G., Bisseret P., Blanchard N.
    Comptes Rendus Chimie, 2017, 20, 643-647 (OPEN ACCESS)
  • Desymmetrizing Hydroformylation of Dihydromuconic Acid Diesters: Application to the Synthesis of (+/-)-Vindeburnol
    Salacz L., Charpentier C., Suffert J., Girard N.
    J. Org. Chem.
    , 2017, 82, 2257-2262

  • Synthesis of original polycycles containing 5, 6 and 7-membered rings through cyclocarbopalladations/CH-activation cascade reactions.
    Joussot J., Schoenfelder A., Suffert J., Blond G.
    Comptes Rendus Chimie, 2017, 20, 665-681 (OPEN ACCESS)
  • Cyclocarbopalladation as a key step in cascade reactions: recent developments.
    Blouin S., Blond G., Donnard M., Gulea M., Suffert J.
    Synthesis
    , 2017, 49, 1767-1784

  • Comparative study on the reactivity of propargyl and alkynyl sulfides in Palladium-catalyzed domino reactions
    Castanheiro T., Suffert J., Donnard M., Gulea M.
    Comptes Rendus Chimie, 2017,
    20, 624-633 (OPEN ACCESS)

  • Hopping of Palladium: Access to Original Polycyclic Structures Containing Three-, Four-, Five- and Six-Membered Rings
    Ghosh N., Maiereanu C., Suffert J., Blond G.
    Synlett,
    2017, 28, 451-455

  • Synthesis of Sulfur Heterocycles via Domino Metal-Mediated Reactions
    Castanheiro T., Suffert J., Donnard M., Gulea M.
    Phosphorus Sulfur Silicon Relat. Elem.
    , 2017, 192, 162

  • Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells.
    Emhemmed F., Ali Azouaou S., Zhao Q., Appert-Collin A., Bennasroune A., Schini-Kerth V.B., Muller C.D., Désaubry L., Fuhrmann G.
    Cell Biol Toxicol., 2017, ASAP


2016

  • Recent Contributions to Hetero Diels-Alder Reactions
    Blond G., Gulea M., Mamane V.
    Curr. Org. Chem.
    , 2016, 20, 2161

  • A Step-Economical Multicomponent Synthesis of 3D-Shaped Aza-Diketopiperazines and Their Drug-like Chemical Space Analysis
    Regenass P.M., Riché S., Peron F., Rognan D., Hibert M., Girard N., Bonnet D.
    Org. Biomol. Chem.,
    2016, 14, 8859-8863

  • A general and efficient synthesis of 2-pyridones, 2-quinolinones and 1-isoquinolinones from azine-N-oxides.
    Wang D., Zhao J., Wang Y., Hu J., Li L., Miao L., Feng H., Désaubry L;, Yu P.
    Asian J. Org. Chem.
    2016, 5, 1442-1446

  • Molecular pathways: the eIF4F translation initiation complex –new opportunities for cancer treatment.
    Malka-Mahieu H., Newman M., Désaubry L., Robert C., Vagner S.
    Clin Cancer Res.
    , 2016, 22, in press

  • Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines.
    Malka-Mahieu H., Girault I., Rubington M., Leriche M., Welsch C., Kamsu-Kom N., Zhao Q., Désaubry L., Vagner S., Robert C.
    Cell cycle
    , 2016, 15, 2405-2409

  • Synthesis of hydroxybenzofurans by condensation of quinones with benzoylacetone: revised structure of the adducts.
    Hammoud H., Zhao Q., Désaubry L. 
    Tetrahedron Lett., 2016,
    57, 4044–4045

  • STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A.
    Wang S, Darini C, Désaubry L, Koromilas AE.
    Mol Cancer Ther.
    ,
    2016,  15, 3055-3063

  • Synthesis of 3-Substituted Chromones and Quinolones from Enaminones
    Joussot J., Schoenfelder A., Larquetoux L., Nicolas M., Suffert J., Blond G.
    Synthesis, 2016, 48, 3364-3372

  • Bioisosteric modification of flavaglines
    Qian Z., Tijeras-Raballand A., de Gramont A., Raymond E., Désaubry L.
    Tetrahedron Lett.
    , 2016, 57, 2943

  • Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives.
    Castanheiro T., Suffert J., Gulea M., Donnard M.
    Org. Lett., 2016, 18, 2588   (OPEN ACCESS)

  • Synthesis of Cyclooctatetraenes through a Palladium-Catalyzed Cascade Reaction.
    Blouin S., Gandon V., Blond G., Suffert J.
    Angew. Chem. Int. Ed.,
    2016, 55, 7208

  • Recent Advances in the Chemistry of Organic Thiocyanates.
    Castanheiro T., Suffert J., Donnard M., Gulea M.
    Chem. Soc. Rev., 2016, 45, 494-505

  • Flavaglines ameliorate experimental colitis and protect against intestinal epithelial cell apoptosis and mitochondrial dysfunction.
    Han J., Zhao Q., Basmadjian C., Désaubry L., Theiss A.L.
    Inflamm. Bowel Dis
    .
    2016, 22, 55-67

  • Recent advances in the synthesis of flavaglines, a family of potent bioactive natural compounds coming from traditional Chinese medicine.
    Zhao Q., Abou-Hamdan H., Désaubry L.
    Eur. J. Org. Chem.
    , 2016, 5908-5916

  • Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.
    Fleury A., Hoch L., Martinez MC, Faure H., Taddei M., Petricci E., Manetti F., Girard N., Mann A., Jacques C., Larghero J., Ruat m., Adriantsitohaina R., LeLay S.
    Scientific Reports
    , 2016, 23479

 


2015

  • Discovery and cardioprotective effects of the first non-peptide agonists of the G protein-coupled prokineticin receptor-1.
    Gasser A., Brogi S., Urayama K., Nishi T., Kurose H., Tafi A., Ribeiro N., Désaubry L., Nebigil CG.
    Plos One.
    2015, 10, e0121027

  • Revision of the synthesis and pharmacological activity of a reported translation inhibitor.
    Basmadjian C., Malka-Mahieu H., Désaubry L.
    Anticancer Agents Med. Chem.
    2015, 15, 1305-1307
  • Flavaglines stimulate transient receptor potential melastatin type 6 (TRPM6) channel activity.
    Blanchard MG., de Baaij J.H.F., Verkaart S.A.J., Lameris A.L., Basmadjian C., Zhao Q., Désaubry L., Bindels R.J.M., Hoenderop JG.
    Plos One 2015, 10, e0119028.

     

  • MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the smoothened receptor.

    Hoch, L.; Faure, H.; Roudaut, H.; Schoenfelder, A.; Mann, A.; Girard, N.; Bihannic, L.; Ayrault, O.; Petricci, E.; Taddei, M.
    FASEB 2015, 19, 1817-1829
  • Assessment of flavaglines as potential chikungunya virus entry inhibitors.
    Wintachai, P.; Thuaud, F.; Basmadjian, C.; Ubol, S.; Désaubry, L.; Smith, D.R.
    Microbiol. Immunol. 2015, 59, 129-141

  • Exploratory studies toward a synthesis of flavaglines . A novel access to a highly substituted. cyclopentenone intermediate
    Basmadjian, C.; Zhao, Q.; Désaubry, L.
    Tetrahedron Lett.
    2015, 56, 727–730.


2014

  • Practical access to aromatic thiocyanates by CuCN-mediated direct aerobic oxidative cyanation of thiophenols and diaryl disulfides.
    Castanheiro, T.;  Gulea, M.; Donnard, M.; Suffert, J.
    Eur. J. Org. Chem., 2014, 2014, 7814-7817.
  • eIF4F is a key and targetable convergence nexus of multiple resistance mechanisms to anti-RAF and anti-MEK cancer therapies.
    Boussemart, L.; Malka-Mahieu, H.; Girault, I.; Allard, D.; Hemmingsson, O.; Tomasic, G.; Thomas, M.; Basmadjian, C.; Ribeiro, N.; Thuaud, F.; Mateus, C.; Routier, E.; Kamsu-Kom, N.; Agoussi, S.; Eggermont, A. M.; Désaubry, L.; Robert, C.; Vagner, S.
    Nature 2014, 513, 105–109.

  • Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process.
    Regenass, P.; Margathe, J.-F.; Mann, A.; Suffert, J.; Hibert, M.; Girard, N.; Bonnet, D.
    Chem. Commun. 2014, 50, 9657–9660.

  • Cyclocarbopalladation/cross-coupling cascade reactions in sulfide series: access to sulfur heterocycles.
    Castanheiro, T.; Donnard, M.; Gulea, M.; Suffert, J.
    Org. Lett.
    2014, 16, 3060–3063.
  • Benzofuran derivatives as anticancer inhibitors of mTOR signaling.
    Salomé, C.; Ribeiro, N.; Chavagnan, T.; Thuaud, F.; Serova, M.; de Gramont, A.; Faivre, S.; Raymond, E.; Désaubry, L.
    Eur. J. Med. Chem.
    2014, 81, 181–191.

  • Cancer wars: natural products strike back.
    Basmadjian, C.; Zhao, Q.; Bentouhami, E.; Djehal, A.; Nebigil, C. G.; Johnson, R. A.; Serova, M.; de Gramont, A.; Faivre, S.; Raymond, E.; Désaubry, L. G.
    Front. Chem.
    2014, 2, 20.

  • Electrochemical Access to 8-(1-Phenyl-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane-7-carbonitrile. Application to the Asymmetric Syntheses of (+)-Myrtine and Alkaloid (+)-241D.
    Vu, V. H.; Louafi, F.; Girard, N.; Marion, R.; Roisnel, T.; Dorcet, V.; Hurvois, J.-P.
    J. Org. Chem. 2014, 79, 3358–3373.

  • Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.
    Emhemmed, F.; Ali Azouaou, S.; Thuaud, F.; Schini-Kerth, V.; Désaubry, L.; Muller, C. D.; Fuhrmann, G.
    Biochem. Pharmacol. 2014, 89, 185–196.

  • Benzofuran derivatives as a novel class of inhibitors of mTOR signaling.
    Salomé, C.; Narbonne, V.; Ribeiro, N.; Thuaud, F.; Serova, M.; de Gramont, A.; Faivre, S.; Raymond, E.; Désaubry, L.
    Eur. J. Med. Chem.
    2014, 74, 41–49.

  • Copper-catalyzed C-C bond formation in natural product synthesis: elegant and efficient solution to a key bond disconnection
    (book chapter)

    Nicolas Blanchard; Morgan Donnard
    chapter 18 in Copper-Mediated Cross-Coupling Reactions; Evano G.; Blanchard, N. Eds.; John Wiley & Sons: Hoboken, 2014, pp 683-723.