Plateforme de Synthèse Organique (PSO)
Responsable : Patrick WAGNER
Jaques BRICARD - Ingénieur d'études
Patrick WAGNER - Ingénieur d'études
Camille VAN WESEMAEL - Assistante Ingénieur
Objectif et Vision
Récemment nous avons décidé de mettre en place une gestion mutualisée d'ITA volontaires (P. Wagner, J. Bricard, C. Van Wesemael) au moyen d'appels à projets internes à l'Unité dont le but est de fournir une assistance technique temporaire (3 mois, 6 mois, 1 an) à des projets de natures diverses (preuve de concept, pré-maturation en vue d'un appel à projet type ANR ou Labex, exemplification en vue d'un dépôt de brevet) soumis au Comité de Pilotage qui décide de l'affectation-projet de ces trois ITA. Ces trois collègues contribuent à une plateforme technique de synthèse sédentarisée dans des locaux qui lui sont propres.
Étudiants
- Steven Zapata (Master 2, 2023)
- Lylou Fuchs (DUT 2ème année, 2023)
- Alice Saviard (Master 2, 2022)
- Aurore Didier (Licence 3, 2021)
Publications Récentes
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Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels−Alder Cycloaddition: Application to Apelin
Timothé Maujean, Patrick Wagner, Christel Valencia, Stéphanie Riché, Xavier Iturrioz, Pascal Villa, Nicolas Girard, Julie Karpenko, Mihaela Gulea and Dominique Bonnet
Bioconjug Chem. 2023 Jan 18;34(1):162-168
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Catalyst-free thia-Diels-Alder click reaction for the labeling of peptides for imaging applications
Timothé Maujean, Patrice Marchand, Patrick Wagner, Stéphanie Riché, Frédéric Boisson, Nicolas Girard, Julie Karpenko, Dominique Bonnet and Mihaela Gulea
Phosphorus, Sulfur, and Silicon and the Related Elements
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Synthesis of new N/S-containing compounds by Pd-catalyzed tandem reactions
Basilio Lopes A., Wagner P., Choury M., Gulea M.
Phosphorus, Sulfur, and Silicon and the Related Elements
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Gold(I)-Catalyzed Carbothiolation via Rearrangement of S-Propargyl Group: An Access to 3-Allenyl or 3-Indenyl Benzo[b]thiophenes
C. Van Wesemael, N. Brach, M. Gulea, G. Blond
Adv. Synth. Catal. 2022, 364, 4141
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Hetero-Diels–Alder click reaction of dithioesters for a catalyst-free indirect 18F-radiolabelling of peptides
Timothé Maujean, Patrice Marchand, Patrick Wagner, Stéphanie Riché, Frédéric Boisson, Nicolas Girard, Dominique Bonnet and Mihaela Gulea
Chem. Commun., 2022, 58, 11151-11154 -
Access to 1,4-Thiazepanes via Gold-Catalyzed 7-exo-dig Thioallylation and their Cycloisomerization to Bicyclic [4.3.1] Bridgehead-Olefinic Systems
Mickael Choury, Patrick Wagner, Charlou Rognan, Gaëlle Blond, and Mihaela Gulea
Adv. Synth. Catal. 2022, 364, 1 – 8 -
Cyclocarbopalladation/Stille Cascade: Stereoselective Access to Quaternary Functionalized Carbons
Océane Flores, Patrick Wagner, and Jean Suffert
Org. Lett. 2021, 23, 16, 6568–6572 - Diastereoselective Synthesis of Nonplanar 3-Amino-1,2,4-oxadiazine Scaffold: Structure Revision of Alchornedine
Tang SQ, Leloire M, Schneider S, Mohr J, Bricard J, Gizzi P, Garnier D, Schmitt M, Bihel F
J. Org. Chem, 2020, 85, 23, 15347–15359
- Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis
Ruch M., Brach N., Galéa R., Wagner P., Blond G.
Molecules, 2020, 25, 4976
- Solvent Effect in Gold(I)-Catalyzed Domino Reaction: Access to Furopyrans
Wagner P., Ghosh N., Gandon V., Blond G.
Org. Lett., 2020, 22, 18, 7333–7337
- Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP
Tang SQ, Bricard J, Schmitt M, Bihel F
Org. Lett., 2019, 21, 3, 844-48
- Ligand-Controlled Regiodivergent Hydroformylation of Ynamides: A Stereospecific and Regioselective Access to 2- and 3-Aminoacroleins.
Wagner, P.; Donnard, M.; Girard, N.
Org. Lett., 2019, 21, 21, 8861-8866.
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Gold(I)-Catalyzed Synthesis of Furopyrans: Insight into Hetero-Diels–Alder Reactions.
Pertschi R., Wagner P., Ghosh N., Gandon V., Blond, G.
Org. Lett., 2019, 21, 6084-6088. - Tandem Double-Cross-Coupling/Hydrothiolation Reaction of 2-Sulfenyl Benzimidazoles with Boronic Acids.
Basilio Lopes A., Choury M., Wagner P., Gulea, M.
Org. Lett., 2019, 21, 5943-5947 -
Synthesis of benzimidazole‐fused medium‐sized N,S‐heterocycles via palladium‐catalyzed cyclizations.
Basilio Lopes A., Wagner P., Gulea M.
Eur. J. Org. Chem., 2019, 1361-1370. -
Synthesis of Benzo[c]silole derivatives Bearing a Tetrasubstituted Exocyclic C=C Double Bond by Palladium-Catalyzed Domino Reactions.
Wagner P., Gulea M., Suffert J., Donnard M.
Chem. Eur. J., 2017, 23, 7458-7462
