Publications


2020

  • A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice
    Lucie Esteoulle;  François Daubeuf;  Mayeul Collot;  Stéphanie Riché;  Thierry Durroux;  David Brasse;  Patrice Marchand;  Iuliia A. Karpenko;  Andrey S. Klymchenko;  Dominique Bonnet
    Chemical Science
    2020; DOI: 10.1039/D0SC01018A
  • Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.
    Fellous TG, Redpath AN, Fleischer MM, Gandhi S, Hartner SE, Newton MD, François M, Wong SP, Gowers KHC, Fahs AM, Possley DR, Bonnet D, Urquhart P, Nicolaou A, Baker KC, Rankin SM.
    NPJ Regen Med. 2020
    Feb 21;5:3. doi: 10.1038/s41536-020-0088-1. eCollection 2020.
  • Neutralization of CXCL12 attenuates established pulmonary hypertension in rats.
    Bordenave J, Thuillet R, Tu L, Phan C, Cumont A, Marsol C, Huertas A, Savale L, Hibert M, Galzi JL, Bonnet D, Humbert M, Frossard N, Guignabert C.
    Cardiovasc Res.
    2020 Mar 1;116(3):686-697. doi: 10.1093/cvr/cvz153.
  • A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain.
    Hilfiger L, Zhao Q, Kerspern D, Inquimbert P, Andry V, Goumon Y, Darbon P, Hibert M, Charlet A.
    Sci Rep.
    2020 Feb 20;10(1):3017. doi: 10.1038/s41598-020-59929-w.

2019

  • Chemoselective Acylation of Hydrazinopeptides to Access Fluorescent Probes for Time-Resolved FRET Assays on GPCRs.
    Ramanoudjame S.M.; Esteoulle L.; Riché S.; Margathe J.F.; Durroux T.; Karpenko I.A.; Bonnet D.
    Methods Mol Biol.
    2019; 1947:137-147. doi: 10.1007/978-1-4939-9121-1_7. Walker J.M., Series Editor; Tiberi M. Editor; G Protein-Coupled Receptor Signaling Methods and Protocols
  • Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology
    Heuninck J.; Hounsou C.; Dupuis E.; Trinquet E.; Mouillac B.; Pin J.P.; Bonnet D.; Durroux T.
    Methods Mol Biol.
    2019; 1947:151-168. doi: 10.1007/978-1-4939-9121-1_8. Walker J.M., Series Editor; Tiberi M. Editor; G Protein-Coupled Receptor Signaling Methods and Protocols
  • A l’ombre d’Eros: une chimie de l’Amour ?
    Marcel Hibert et Dominique Bonnet
    L’actualité chimique
    , 2019, n°444-445, 61-67

2018

  • Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia
    Regenass, P.; Abboud, D.; Daubeuf, F; Lehalle, C; Gizzi, P; Riche, S; Hachet-Haas, M ; Rohmer, F; Gasparik, V; Boeglin, D; Haiech, J; Knehans, T; Rognan, D; Heissler, D; Marsol, C; Villa, P; Galzi, JL; Hibert, M; Frossard, N; Bonnet, D.
    J. Med. Chem.,
    2018, 61, 7671-7686
  • « Highlight » sur le site CNRS : un « neutraligand » pour combattre les maladies inflammatoires
    Bonnet, D.
    En direct des
    laboratoires de l'Institut de Chimie, 2018
    http://www.cnrs.fr/inc/communication/direct_labos/bonnet4.htm
  • LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism
    Frantz, M.C.; Pellissier, L.P.; Pflimlin, E.; Loison, S.; Gandia, J.; Marsol, C.; Durroux, T.; Mouillac, B.; Becker, J.A.J.; Le Merrer, J; Valencia, C.; Villa, P.; Bonnet, D.; Hibert, M.
    J. Med. Chem.,
    2018, 61, 8670-8692
  • Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines
    Péron, F.; Riché, S.; Lesur, B.; Hibert, M.; Breton, P.; Fourquez, J.-M.; Girard, N.; Bonnet, D.
    ACS Omega
    , 2018, 3 (11), pp 15182–15192
  • From the Promiscuous Asenapine to Potent Fluorescent Ligands Acting at a Series of Aminergic G-Protein-Coupled Receptors
    Hounsou, C.; Baehr, C.; Gasparik, V.; Alili, D.; Belhocine, A.; Rodriguez, T.; Dupuis, E.; Roux, T.; Mann, A.; Heissler, D.; Pin, J.P.; Durroux, T.; Bonnet, D.; Hibert, M.
    J. Med. Chem.,
    2018, 1, 174-188

2017

  • Decreased Migration of Dendritic Cells into the Jugular-Nodose Ganglia by the CXCL12 Neutraligand Chalcone 4 in Ovalbumin-Sensitized Asthmatic Mice
    Heck, S.; Daubeuf, F.; Le, D.D.; Sester, M.; Bonnet, D.; Bals, R.; Frossard, N.; Dinh, Q.T.
    Neuroimmunomodulation, 2017, 24, 331-340
  • Two distinct CXCR4 antagonists mobilise progenitor cells in mice by different mechanisms
    Redpath, N.A.; Francois, M.; Wong, S.-P.; Bonnet, D.; Rankin, M.S.
    Blood Advances
    , 2017, 22, 1934-1943.
  • Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines
    Regenass, P.; Bosc, D.; Riche, S.; Gizzi, P.; Hibert, M.; Karmazin, L.; Ganesan, A.; Bonnet, D.
    J.
    Org. Chem., 2017, 82, 3239-3244   
  • A time-resolved FRET cell-based binding assay for the apelin receptor
    Valencia, C; Dujet, C; Margathe, JF; Iturrioz, X; Roux, T; Trinquet, E; Villa, P; Hibert, M; Dupuis, E; Llorens-Cortes, C; Bonnet, D.
    Chem. Med. Chem.
    , 2017, 12, 925-931.
  • Development of original metabolically-stable apelin-17 analogs with diuretic and cardiovascular effects
    Gerbier, R.; Alvear-Perez,R.; Margathe, J.F.; Flahault, A.; Couvineau, P.; Gao, J.; De Mota, N.; Dabire, H.; Li, B.; Ceraudo, E.; Hus-Citharel, A.; Esteoulle, L.; Bisoo, C.; Hibert, M.; Berdeaux, A.; Iturrioz, X.; Bonnet, D.; Llorens-Cortes, C.
    FASEB J.
    , 2017, 31, 687-700

2016

  • Development of original metabolically-stable apelin-17 analogs with diuretic and cardiovascular effects.
    Gerbier, R.; Alvear-Perez,R.; Margathe, J.F.; Flahault, A.; Couvineau, P.; Gao, J.; De Mota, N.; Dabire, H.; Li, B.; Ceraudo, E.; Hus-Citharel, A.; Esteoulle, L.; Bisoo, C.; Hibert, M.; Berdeaux, A.; Iturrioz, X.; Bonnet, D.; Llorens-Cortes, C.
    FASEB J, 2016, doi:10.1096/fj.201600784R.

  • A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis
    Regenass, P.; Riche, S.; Peron, F.; Rognan, D.;Hibert, M.;Girard, N. and Bonnet, D.
    Org Biomol Chem, 2016, 14, 8859-8863

  • Convenient access to fluorescent probes by chemoselective acylation of hydrazinopeptides: Application to the synthesis of the first far-red ligand for Apelin receptor imaging
    Margathe, J.F.; Iturrioz, X.;Regenass, P.; Karpenko, I.A.;Humbert, N.;De Rocquigny, H.; Hibert, M.;  Llorens-Cortes, C.; Bonnet, D.
    Chem Eur J, 2016, 22, 1399-1405

  • Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions
    Karpenko, I. A.;Niko, Y.;Yakubovskyi, V. P.;Gerasov, A. O.;Bonnet, D.;Kovtun, Y. P. and Klymchenko, A. S.
    J Mater Chem C, 2016, 4, 3002-3009

 

2015

  • New fluorescein precursors for live bacteria detection.
    Guilini, C.; Baehr, C.; Schaeffer, E.; Gizzi, P.; Rufi, F.; Haiech, J.; Weiss, E.; Bonnet, D.; Galzi J.L.
    Anal Chem.
    2015, 87, 8858-8866
  • Convenient access to fluorescent probes by chemoselective acylation of hydrazinopeptides: Application to the synthesis of the first far-red ligand for Apelin receptor imaging
    Margathe, J.F.; Iturrioz, X.;Regenass, P.; Karpenko, I.A.;Humbert, N.;De Rocquigny, H.; Hibert, M.;  Llorens-Cortes, C.; Bonnet, D.
    Chem Eur J
    , 2015, DOI: chem.201503630.
  • Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions
    Karpenko, I.A.; Niko, Y.; Gerasov, A.O.; Yakubovskyi, V.P.; Bonnet, D.; Kovtun Y.P., Klymchenko, A.S.
    J Mater Chem
    , 2015, DOI: 10.1039/C5TC03411 
  • Selective Non-Peptidic Fluorescent Ligands for Oxytocin Receptor: Design, Synthesis and Application to Time-Resolved FRET Binding Assay
    Karpenko, I.A.; Margathe, J.-F.; Rodriguez, T.; Hibert, M.; Durroux,T.; Bonnet, D.
    J Med Chem, 2015, 58, 2547-2552
  • Squaraine as bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging
    Karpenko, I.A.; Klymchenko A. S.; Gioria, S.; Kreder, R.; Shulov, I.; Villa, P.; Mély, Y.; Hibert, M.; Bonnet, D.
    Chem Commun, 2015, 51, 2960-2963
  • A strategy to discover decoy chemokine ligands with an anti-inflammatory activity
    Abboud, D.; Daubeuf, F.; Do, Q.T.; Utard, V; Villa, P.; Haiech, J.; Bonnet, D; Hibert, M.; Bernard, P.; Galzi, J.L.; Frossard, N.
    Scientific Reports,
    2015, 5, 14746, DOI: 10.1038/srep14746
  • Increasing cellular immunogenicity to peptide-based vaccine candidates using a
    fluorocarbon antigen delivery system

    Francis, J.N; Thaburet, J-F.; Bonnet, D.; Sizer, P.J.; Brown, C.B.; Georges, B.
    Vaccine
    , 2015, 33, 1071-1076
  • Time-Resolved FRET binding assay to investigate hetero-oligomer binding   properties: proof of concept with dopamine D1/D3 heterodimer.
    Hounsou, C.; Margathe, J. F.; Oueslati, N.; Belhocine, A.; Dupuis, E.; Thomas, C.; Mann, A.; Ilien, B.; Rognan, D.; Trinquet, E.; Hibert, M.; Pin, J. P.; Bonnet, D. and Durroux. T.
    ACS ChemBiol,
    2015, 10, 466-474

« Highlight » sur le site CNRS: Un essai innovant basé sur la fluorescence pour étudier la pharmacologie des complexes de récepteurs couplés aux protéines G; Bonnet, D. et Durroux, T.; http://www.cnrs.fr/inc/communication/direct_labos/bonnet2.htm

  • Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging
    Karpenko, I.A.; Collot, M.; Richert, L.; Valencia, C.; Villa, P.; Mély, Y.; Hibert, M.; Bonnet, D. and Klymchenko A. S.
    J Am Chem Soc
    , 2015, 137, 405-412.
  • Fluorogenic dye tweezers coax cells to glow red
    Karpenko, I.A.; Collot, M.; Richert, L.; Valencia, C.; Villa, P.; Mély, Y.; Hibert, M.; Bonnet, D. and Klymchenko A. S.
    J Am Chem Soc Spotlights
    2015, 137, 1-1

2014

  • Time-Resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer.
    Hounsou, C.;Margathe, J. F.;Oueslati, N.;Belhocine, A.;Dupuis, E.;Thomas, C.;Mann, A.;Ilien, B.;Rognan, D.;Trinquet, E.;Hibert, M.;Pin, J. P.;Bonnet, D. and Durroux, T.
    ACS ChemBiol. 2014, DOI: 10.1021/cb5007568,

  • Quantitative Structure-Property Relationship Modeling: A Valuable Support in High-Throughput Screening Quality Control
    Ruggiu, F.;Gizzi, P.;Galzi, J. L.;Hibert, M.;Haiech, J.;Baskin, I.;Horvath, D.;Marcou, G. and Varnek, A.
    Analytical Chemistry 2014, 86, 2510-2520

  • Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process
    Regenass, P.;Margathe, J. F.;Mann, A.;Suffert, J.;Hibert, M.;Girard, N. and Bonnet, D.
    Chemical Communications 2014, 50, 9657-9660

  • Structure Activity Relationship Studies toward the Discovery of Selective Apelin Receptor Agonists
    Margathe, J. F.;Iturrioz, X.;Alvear-Perez, R.;Marsol, C.;Riche, S.;Chabane, H.;Tounsi, N.;Kuhry, M.;Heissler, D.;Hibert, M.;Llorens-Cortes, C. and Bonnet, D.
    Journal of Medicinal Chemistry
    2014, 57, 2908-2919

  • Coordination Cluster Analogues of the High-Spin [Mn-19] System with Functionalized 2,6-Bis(hydroxymethyl)phenol Ligands
    Mameri, S.;Ako, A. M.;Yesil, F.;Hibert, M.;Lan, Y. H.;Anson, C. E. and Powell, A. K.
    European Journal of Inorganic Chemistry 2014, 4326-4334

  • Red Fluorescent Turn-On Ligands for Imaging and Quantifying G Protein-Coupled Receptors in Living Cells
    Karpenko, I. A.;Kreder, R.;Valencia, C.;Villa, P.;Mendre, C.;Mouillac, B.;Mely, Y.;Hibert, M.;Bonnet, D. and Klymchenko, A. S.
    Chembiochem 2014, 15, 359-363

  • Design of a General-Purpose European Compound Screening Library for EU-OPENSCREEN
    Horvath, D.;Lisurek, M.;Rupp, B.;Kuhne, R.;Specker, E.;von Kries, J.;Rognan, D.;Andersson, C. D.;Almqvist, F.;Elofsson, M.;Enqvist, P. A.;Gustavsson, A. L.;Remez, N.;Mestres, J.;Marcou, G.;Varnek, A.;Hibert, M.;Quintana, J. and Frank, R.
    Chemmedchem 2014, 9, 2309-2326

2013

  • Exploration of the Orthosteric/Allosteric Interface in Human M1 Muscarinic Receptors by Bitopic Fluorescent Ligands
    Daval, S. B.;Kellenberger, E.;Bonnet, D.;Utard, V.;Galzi, J. L. and Ilien, B.
    Molecular Pharmacology 2013, 84, 71-85

  • An Antedrug of the CXCL12 Neutraligand Blocks Experimental Allergic Asthma without Systemic Effect in Mice
    Daubeuf, F.;Hachet-Haas, M.;Gizzi, P.;Gasparik, V.;Bonnet, D.;Utard, V.;Hibert, M.;Frossard, N. and Galzi, J. L.
    Journal of Biological Chemistry
    2013, 288, 11865-11876

2012

  • Use of an alpha 5 beta 1 Small Non-peptidic Antagonist to Inhibit Glioblastoma Migration Fostered by Integrin Expression
    Ray, A.;Janouskova, H.;Lehmann, M.;Bonnet, D.;Villa, P.;Brino, L.;Martin, S.;Rebel, I. L.;Rognan, D. and Dontenwill, M.
    European Journal of Cancer 2012, 48, S244-S244

  • Selective Fluorescent Nonpeptidic Antagonists For Vasopressin V-2 GPCR: Application To Ligand Screening and Oligomerization Assays
    Loison, S.;Cottet, M.;Orcel, H.;Adihou, H.;Rahmeh, R.;Lamarque, L.;Trinquet, E.;Kellenberger, E.;Hibert, M.;Durroux, T.;Mouillac, B. and Bonnet, D.
    Journal of Medicinal Chemistry 2012, 55, 8588-8602

  • Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo
    Gasparik, V.;Daubeuf, F.;Hachet-Haas, M.;Rohmer, F.;Gizzi, P.;Haiech, J.;Galzi, J. L.;Hibert, M.;Bonnet, D. and Frossard, N.
    Acs Medicinal Chemistry Letters 2012, 3, 10-14

  • Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors
    Daval, S. B.;Valant, C.;Bonnet, D.;Kellenberger, E.;Hibert, M.;Galzi, J. L. and Ilien, B.
    Journal of Medicinal Chemistry
    2012, 55, 2125-2143

  • Involvement of the TGF beta pathway in the regulation of alpha(5)beta(1) integrins by caveolin-1 in human glioblastoma
    Cosset, E. C.;Godet, J.;Entz-Werle, N.;Guerin, E.;Guenot, D.;Froelich, S.;Bonnet, D.;Pinel, S.;Plenat, F.;Chastagner, P.;Dontenwill, M. and Martin, S.
    International Journal of Cancer 2012, 131, 601-611

  • Combinatorial Aid for Underprivileged Scaffolds: Solution and Solid-phase Strategies for a Rapid and Efficient Access To Novel Aza-diketopiperazines (Aza-DKP)
    Bonnet, D.;Margathe, J. F.;Radford, S.;Pflimlin, E.;Riche, S.;Doman, P.;Hibert, M. and Ganesan, A.
    Acs Combinatorial Science
    2012, 14, 323-334

  • Adsorption of [Mn-19] Aggregates with S=83/2 onto HOPG Surfaces
    Ako, A. M.;Alam, M. S.;Mameri, S.;Lan, Y. H.;Hibert, M.;Stocker, M.;Muller, P.;Anson, C. E. and Powell, A. K.
    European Journal of Inorganic Chemistry 2012, 4131-4140

  • Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice
    Balabanian, K.;Brotin, E.;Biajoux, V.;Bouchet-Delbos, L.;Lainey, E.;Fenneteau, O.;Bonnet, D.;Fiette, L.;Emilie, D. and Bachelerie, F.
    Blood
    2012, 119, 5722-5730