Publications


2017

  • A Comparative Study of the Synthesis, Structural and Physicochemical Properties of Diketopiperazines vs Aza-Diketopiperazines
    Regenass, P.; Bosc, D.; Riché, S.; Gizzi, P.; Hibert, M.; Ganesan, A.; Bonnet, D.
    J. Org. Chem., 2017, DOI: 10.1021/acs.joc.6b02895

  • Time-Resolved FRET Cell-Based Binding Assay For Apelin Receptor
    Valencia, C.; Dujet,C.; Margathe,J.-F.; Iturrioz,X.; Roux,T.; Trinquet, E.; Villa,P.; Hibert,M.; Dupuis,E.; Llorens-Cortes,C.; Bonnet, D.
    Chem. Med. Chem.2017DOI: 10.1002/cmdc.201700106

2016

  • Development of original metabolically-stable apelin-17 analogs with diuretic and cardiovascular effects.
    Gerbier, R.; Alvear-Perez,R.; Margathe, J.F.; Flahault, A.; Couvineau, P.; Gao, J.; De Mota, N.; Dabire, H.; Li, B.; Ceraudo, E.; Hus-Citharel, A.; Esteoulle, L.; Bisoo, C.; Hibert, M.; Berdeaux, A.; Iturrioz, X.; Bonnet, D.; Llorens-Cortes, C.
    FASEB J, 2016, doi:10.1096/fj.201600784R.

  • A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis
    Regenass, P.; Riche, S.; Peron, F.; Rognan, D.;Hibert, M.;Girard, N. and Bonnet, D.
    Org Biomol Chem, 2016, 14, 8859-8863

  • Convenient access to fluorescent probes by chemoselective acylation of hydrazinopeptides: Application to the synthesis of the first far-red ligand for Apelin receptor imaging
    Margathe, J.F.; Iturrioz, X.;Regenass, P.; Karpenko, I.A.;Humbert, N.;De Rocquigny, H.; Hibert, M.;  Llorens-Cortes, C.; Bonnet, D.
    Chem Eur J, 2016, 22, 1399-1405

  • Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions
    Karpenko, I. A.;Niko, Y.;Yakubovskyi, V. P.;Gerasov, A. O.;Bonnet, D.;Kovtun, Y. P. and Klymchenko, A. S.
    J Mater Chem C, 2016, 4, 3002-3009

 

2015

  • New fluorescein precursors for live bacteria detection.
    Guilini, C.; Baehr, C.; Schaeffer, E.; Gizzi, P.; Rufi, F.; Haiech, J.; Weiss, E.; Bonnet, D.; Galzi J.L.
    Anal Chem.
    2015, 87, 8858-8866
  • Convenient access to fluorescent probes by chemoselective acylation of hydrazinopeptides: Application to the synthesis of the first far-red ligand for Apelin receptor imaging
    Margathe, J.F.; Iturrioz, X.;Regenass, P.; Karpenko, I.A.;Humbert, N.;De Rocquigny, H.; Hibert, M.;  Llorens-Cortes, C.; Bonnet, D.
    Chem Eur J
    , 2015, DOI: chem.201503630.
  • Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions
    Karpenko, I.A.; Niko, Y.; Gerasov, A.O.; Yakubovskyi, V.P.; Bonnet, D.; Kovtun Y.P., Klymchenko, A.S.
    J Mater Chem
    , 2015, DOI: 10.1039/C5TC03411 
  • Selective Non-Peptidic Fluorescent Ligands for Oxytocin Receptor: Design, Synthesis and Application to Time-Resolved FRET Binding Assay
    Karpenko, I.A.; Margathe, J.-F.; Rodriguez, T.; Hibert, M.; Durroux,T.; Bonnet, D.
    J Med Chem, 2015, 58, 2547-2552
  • Squaraine as bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging
    Karpenko, I.A.; Klymchenko A. S.; Gioria, S.; Kreder, R.; Shulov, I.; Villa, P.; Mély, Y.; Hibert, M.; Bonnet, D.
    Chem Commun, 2015, 51, 2960-2963
  • A strategy to discover decoy chemokine ligands with an anti-inflammatory activity
    Abboud, D.; Daubeuf, F.; Do, Q.T.; Utard, V; Villa, P.; Haiech, J.; Bonnet, D; Hibert, M.; Bernard, P.; Galzi, J.L.; Frossard, N.
    Scientific Reports,
    2015, 5, 14746, DOI: 10.1038/srep14746
  • Increasing cellular immunogenicity to peptide-based vaccine candidates using a
    fluorocarbon antigen delivery system

    Francis, J.N; Thaburet, J-F.; Bonnet, D.; Sizer, P.J.; Brown, C.B.; Georges, B.
    Vaccine
    , 2015, 33, 1071-1076
  • Time-Resolved FRET binding assay to investigate hetero-oligomer binding   properties: proof of concept with dopamine D1/D3 heterodimer.
    Hounsou, C.; Margathe, J. F.; Oueslati, N.; Belhocine, A.; Dupuis, E.; Thomas, C.; Mann, A.; Ilien, B.; Rognan, D.; Trinquet, E.; Hibert, M.; Pin, J. P.; Bonnet, D. and Durroux. T.
    ACS ChemBiol,
    2015, 10, 466-474

« Highlight » sur le site CNRS: Un essai innovant basé sur la fluorescence pour étudier la pharmacologie des complexes de récepteurs couplés aux protéines G; Bonnet, D. et Durroux, T.; http://www.cnrs.fr/inc/communication/direct_labos/bonnet2.htm

  • Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging
    Karpenko, I.A.; Collot, M.; Richert, L.; Valencia, C.; Villa, P.; Mély, Y.; Hibert, M.; Bonnet, D. and Klymchenko A. S.
    J Am Chem Soc
    , 2015, 137, 405-412.
  • Fluorogenic dye tweezers coax cells to glow red
    Karpenko, I.A.; Collot, M.; Richert, L.; Valencia, C.; Villa, P.; Mély, Y.; Hibert, M.; Bonnet, D. and Klymchenko A. S.
    J Am Chem Soc Spotlights
    2015, 137, 1-1

2014

  • Time-Resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer.
    Hounsou, C.;Margathe, J. F.;Oueslati, N.;Belhocine, A.;Dupuis, E.;Thomas, C.;Mann, A.;Ilien, B.;Rognan, D.;Trinquet, E.;Hibert, M.;Pin, J. P.;Bonnet, D. and Durroux, T.
    ACS ChemBiol. 2014, DOI: 10.1021/cb5007568,

  • Quantitative Structure-Property Relationship Modeling: A Valuable Support in High-Throughput Screening Quality Control
    Ruggiu, F.;Gizzi, P.;Galzi, J. L.;Hibert, M.;Haiech, J.;Baskin, I.;Horvath, D.;Marcou, G. and Varnek, A.
    Analytical Chemistry 2014, 86, 2510-2520

  • Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process
    Regenass, P.;Margathe, J. F.;Mann, A.;Suffert, J.;Hibert, M.;Girard, N. and Bonnet, D.
    Chemical Communications 2014, 50, 9657-9660

  • Structure Activity Relationship Studies toward the Discovery of Selective Apelin Receptor Agonists
    Margathe, J. F.;Iturrioz, X.;Alvear-Perez, R.;Marsol, C.;Riche, S.;Chabane, H.;Tounsi, N.;Kuhry, M.;Heissler, D.;Hibert, M.;Llorens-Cortes, C. and Bonnet, D.
    Journal of Medicinal Chemistry
    2014, 57, 2908-2919

  • Coordination Cluster Analogues of the High-Spin [Mn-19] System with Functionalized 2,6-Bis(hydroxymethyl)phenol Ligands
    Mameri, S.;Ako, A. M.;Yesil, F.;Hibert, M.;Lan, Y. H.;Anson, C. E. and Powell, A. K.
    European Journal of Inorganic Chemistry 2014, 4326-4334

  • Red Fluorescent Turn-On Ligands for Imaging and Quantifying G Protein-Coupled Receptors in Living Cells
    Karpenko, I. A.;Kreder, R.;Valencia, C.;Villa, P.;Mendre, C.;Mouillac, B.;Mely, Y.;Hibert, M.;Bonnet, D. and Klymchenko, A. S.
    Chembiochem 2014, 15, 359-363

  • Design of a General-Purpose European Compound Screening Library for EU-OPENSCREEN
    Horvath, D.;Lisurek, M.;Rupp, B.;Kuhne, R.;Specker, E.;von Kries, J.;Rognan, D.;Andersson, C. D.;Almqvist, F.;Elofsson, M.;Enqvist, P. A.;Gustavsson, A. L.;Remez, N.;Mestres, J.;Marcou, G.;Varnek, A.;Hibert, M.;Quintana, J. and Frank, R.
    Chemmedchem 2014, 9, 2309-2326

2013

  • Exploration of the Orthosteric/Allosteric Interface in Human M1 Muscarinic Receptors by Bitopic Fluorescent Ligands
    Daval, S. B.;Kellenberger, E.;Bonnet, D.;Utard, V.;Galzi, J. L. and Ilien, B.
    Molecular Pharmacology 2013, 84, 71-85

  • An Antedrug of the CXCL12 Neutraligand Blocks Experimental Allergic Asthma without Systemic Effect in Mice
    Daubeuf, F.;Hachet-Haas, M.;Gizzi, P.;Gasparik, V.;Bonnet, D.;Utard, V.;Hibert, M.;Frossard, N. and Galzi, J. L.
    Journal of Biological Chemistry
    2013, 288, 11865-11876

2012

  • Use of an alpha 5 beta 1 Small Non-peptidic Antagonist to Inhibit Glioblastoma Migration Fostered by Integrin Expression
    Ray, A.;Janouskova, H.;Lehmann, M.;Bonnet, D.;Villa, P.;Brino, L.;Martin, S.;Rebel, I. L.;Rognan, D. and Dontenwill, M.
    European Journal of Cancer 2012, 48, S244-S244

  • Selective Fluorescent Nonpeptidic Antagonists For Vasopressin V-2 GPCR: Application To Ligand Screening and Oligomerization Assays
    Loison, S.;Cottet, M.;Orcel, H.;Adihou, H.;Rahmeh, R.;Lamarque, L.;Trinquet, E.;Kellenberger, E.;Hibert, M.;Durroux, T.;Mouillac, B. and Bonnet, D.
    Journal of Medicinal Chemistry 2012, 55, 8588-8602

  • Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo
    Gasparik, V.;Daubeuf, F.;Hachet-Haas, M.;Rohmer, F.;Gizzi, P.;Haiech, J.;Galzi, J. L.;Hibert, M.;Bonnet, D. and Frossard, N.
    Acs Medicinal Chemistry Letters 2012, 3, 10-14

  • Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors
    Daval, S. B.;Valant, C.;Bonnet, D.;Kellenberger, E.;Hibert, M.;Galzi, J. L. and Ilien, B.
    Journal of Medicinal Chemistry
    2012, 55, 2125-2143

  • Involvement of the TGF beta pathway in the regulation of alpha(5)beta(1) integrins by caveolin-1 in human glioblastoma
    Cosset, E. C.;Godet, J.;Entz-Werle, N.;Guerin, E.;Guenot, D.;Froelich, S.;Bonnet, D.;Pinel, S.;Plenat, F.;Chastagner, P.;Dontenwill, M. and Martin, S.
    International Journal of Cancer 2012, 131, 601-611

  • Combinatorial Aid for Underprivileged Scaffolds: Solution and Solid-phase Strategies for a Rapid and Efficient Access To Novel Aza-diketopiperazines (Aza-DKP)
    Bonnet, D.;Margathe, J. F.;Radford, S.;Pflimlin, E.;Riche, S.;Doman, P.;Hibert, M. and Ganesan, A.
    Acs Combinatorial Science
    2012, 14, 323-334

  • Adsorption of [Mn-19] Aggregates with S=83/2 onto HOPG Surfaces
    Ako, A. M.;Alam, M. S.;Mameri, S.;Lan, Y. H.;Hibert, M.;Stocker, M.;Muller, P.;Anson, C. E. and Powell, A. K.
    European Journal of Inorganic Chemistry 2012, 4131-4140

  • Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice
    Balabanian, K.;Brotin, E.;Biajoux, V.;Bouchet-Delbos, L.;Lainey, E.;Fenneteau, O.;Bonnet, D.;Fiette, L.;Emilie, D. and Bachelerie, F.
    Blood
    2012, 119, 5722-5730