Publications
2022
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In Situ Formation of Cationic π-Allylpalladium Precatalysts in Alcoholic Solvents: Application to C–N Bond Formation
Quillet R et al.
ACS Catalysis (2022) DOI : 10.1021/acscatal.1c04641
PDF on Univoak -
Identification of 8‐Hydroxyquinoline Derivatives That Decrease Cystathionine Beta Synthase (CBS) Activity
Conan et al.
Int. J. Mol. Sci. (2022), 23, 6769. DOI : 10.3390/ijms23126769
Post-print PDF on Univoak
2021
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Identification of an N-acylated-D-Arg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia
Quillet R et al.
J Med Chem (2021) DOI : 10.1021/acs.jmedchem.1c00256
Post-print PDF on HAL -
Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors
De Neve J et al
RSC Med Chem (2021) DOI : 10.1039/D1MD00041A
Post-print PDF on Univoak -
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model
Bollenbach M et al
Molecules (2021) 26, 2, 391 DOI : 10.3390/molecules26020391
Post-print PDF on Univoak -
Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation
Bamia et al
Neurotherapeutics (2021) DOI : 10.1007/s13311-020-00992-6
Post-print PDF on Univoak -
Synthesis, Antileishmanial Activity and in silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes
de Aquino et al.
Medicinal Chemistry (2021) DOI : 10.2174/1573406417666210216154428
2020
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Diastereoselective Synthesis of Nonplanar 3-Amino-1,2,4-oxadiazine Scaffold: Structure Revision of Alchornedine
S-Q Tang, M Leloire, S Schneider, J Mohr, J Bricard, P Gizzi, D Garnier, M Schmitt, and F Bihel
J. Org. Chem. (2020) DOI: 10.1021/acs.joc.0c01764
Post-print PDF on HAL -
POxAP Precatalysts and the Negishi Cross-Coupling Reaction
Tang S-Q, Schmitt M, Bihel F
Synthesis (2020) 52, 1, 51-59 DOI: 10.1055/s-0039-1690728
Post-print PDF on Univoak -
Minimizing HCN in DIC/Oxyma mediated amide bond forming reactions
Erny M, Lundqvist M, Rasmussen JH, Ludemann-Hombourger O, Bihel F, Pawlas J
Org. Process Res. Dev. (2020) DOI: 10.1021/acs.oprd.0c00227
Pre-print on ChemRxiv : DOI: 10.26434/chemrxiv.12404252.v1 -
From electronic waste to cross-coupling reactions: direct valuation of recycled palladium in micellar catalysis
Lacanau V, Bonneté F, Wagner P, Schmitt M, Meyer D, Bihel F, Contino-Pepin C, Bourgeois D
ChemSusChem (2020) DOI: 10.1002/cssc.202001155
Cover picture : 10.1002/cssc.202002039
Post-print on HAL -
Indole-3-guanylhydrazone hydrochloride mitigates long-term cognitive impairment in a neonatal sepsis model with involvement of MAPK and NFκB pathways
Heimfarth L et al
Neurochem. Internat. (2020) 134, 104646 (DOI : 10.1016/j.neuint.2019.104647) -
Bioprospecting of Nitrogenous Heterocyclic Scaffolds with Potential Action for Neglected Parasitosis: A Review
Albino SL et al
Current Pharmaceutical Design (2020) 26, 33 (DOI : 10.2174/1381612826666200701160904)
2019
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Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP
Tang S.-Q., Bricard J., Schmitt M., Bihel F.,*
Organic Letters (2019) 21, 3, 844-848 (DOI : 10.1021/acs.orglett.9b00031)
Post-print on HAL -
On water N-arylation of oxetanylamines for the preparation of N-aryl-oxetanylamines; potentially useful aryl-amide isosteres
Bollenbach M, Lecroq W, Wagner P, Fessard T, Schmitt M, Salomé C
Chemical Communication (2019) 55, 1623-1626 (DOI : 10.1039/C8CC09110B) -
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model
Bollenbach, M., Lugnier, C., Kremer, M., Salvat, E., Megat, S., Bihel, F., Bourguignon, J.-J., Barrot, M., and Schmitt
European Journal of Medicinal Chemistry (2019) 177, 269–290. DOI: 10.1016/j.ejmech.2019.05.026
Post-print on HAL -
Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies.
Grimm, A., Lejri, I., Hallé, F., Schmitt, M., Götz, J., Bihel, F., and Eckert, A.
Journal of Neuroendocrinology (2019) DOI: 10.1111/jne.12796 - TSPO ligands boost mitochondrial function and pregnenolone synthesis.
Lejri, I., Grimm, A., Hallé, F., Abarghaz, M., Klein, C., Maitre, M., Schmitt, M., Bourguignon, J.-J., Mensah-Nyagan, A.G., Bihel, F., Eckert A.
Journal of Alzheimer’s Disease (2019) DOI: 10.3233/JAD-190127
- Evolution of coumaroyl conjugate 3‐hydroxylases in land plants: Lignin biosynthesis and defense.
Alber, A.V., Renault, H., Basilio Lopes, A., Bassard, J., Liu, Z., Ullmann, P., Lesot, A., Bihel, F., Schmitt, M., Werck‐Reichhart, D., Ehlting J.
The Plant Journal (2019) DOI: 10.1111/tpj.14373
2018
- Dioxygenation of Styrenes with Molecular Oxygen in Water.
Tang, S.-Q., Wang, A.-P., Schmitt, M., Bihel, F.,*
Tetrahedron Letters 59, 1465–1468
https://doi.org/10.1016/j.tetlet.2018 - Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels.
Alijevic, O., Hammoud, H., Vaithia, A., Trendafilov, V., Bollenbach, M., Schmitt, M., Bihel, F.,* Kellenberger, S.*
ACS Chemical Neuroscience 9, 6, 1357-1365
https://doi.org/10.1021/acschemneuro.7b00529 - Aminoguanidine hydrazone derivatives as non-peptide NPFF1 receptor antagonists reverse opioid induced hyperalgesia.
Hammoud, H., Elhabazi, K., Quillet, R., Bertin, I., Utard, V., Laboureyras, E., Bourguignon, J.-J., Bihel, F., Simonnet, G., Simonin, F.,* Schmitt, M.,*
ACS Chemical Neuroscience 9, 11, 2599-2609
https://doi.org/10.1021/acschemneuro.8b00099.03.009 - Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation.
Bollenbach, M., Salvat, E., Daubeuf, F., Wagner, P., Yalcin, I., Humo, M., Letellier, B., Becker, L.J., Bihel, F., Bourguignon, J.-J., Villa, P., Obrecht, A., Frossard, N., Barrot, M., Schmitt, M.,*
European Journal of Medicinal Chemistry 23, 13676–13683
https://doi.org/10.1016/j.ejmech.2018.01.049 - Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1.
Marginedas-Freixa, I., Alvarez, C.L., Moras, M., Leal Denis, M.F., Hattab, C., Halle, F., Bihel, F., Mouro-Chanteloup, I., Lefevre, S.D., Le Van Kim, C., Schwarzbaum, P.J., Ostuni, M.A.
Scientific Reports 8, 11384 https://doi.org/10.1038/s41598-018-29885-7 - A bifunctional-biased mu-opioid agonist–neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects
Drieu la Rochelle, A., Guillemyn, K., Dumitrascuta, M., Martin, C., Utard, V., Quillet, R., Schneider, S., Daubeuf, F., Willemse, T., Mampuys, P., Maes, B.U.W., Frossard, N., Bihel, F., Spetea, M., Simonin, F., Ballet, S.
PAIN 159, 9, 1705-1718
https://doi.org/10.1097/j.pain.0000000000001262 - Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice.
Rivat, C., Sar, C., Mechaly, I., Leyris, J.-P., Diouloufet, L., Sonrier, C., Philipson, Y., Lucas, O., Mallié, S., Jouvenel, A., Tassou, A., Haton, H., Venteo, S., Pin, J.-P., Trinquet, E., Charrier-Savournin, F., Mezghrani, A., Joly, W., Mion, J., Schmitt, M., Pattyn, A., Marmigère, F., Sokoloff, P., Carroll, P., Rognan, D., Valmier, J.,
Nature Communications 9, 1042
https://doi.org/10.1038/s41467-018-03496-2 - Evidence for the involvement of TNF-α, IL-1β and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents.
Sandes, S.M.S., Heimfarth, L., Brito, R.G., Santos, P.L., Gouveia, D.N., Carvalho, A.M.S., Quintans, J.S.S., da Silva-Júnior, E.F., de Aquino, T.M., França, P.H.B., de Araújo-Júnior, J.X., Albuquerque-Júnior, R.L.C., Zengin, G., Schmitt, M., Bourguignon, J.-J., Quintans-Júnior, L.J.,
Chemico-Biological Interactions 286, 1–10.
https://doi.org/10.1016/j.cbi.2018.02.026
2017
- Efficient and mild Ullmann-type N-arylation of amides, carbamates, and azoles in water.
Bollenbach, M., Aquino, P.G.V., de Araujo-Junior, J.X., Bourguignon, J.-J., Bihel, F., Salome, C., Wagner, P., Schmitt, M.*
Chemistry - A European Journal 23, 13676–13683. https://doi.org/10.1002/chem.201700832 - RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.
Elhabazi, K., Humbert, J.-P., Bertin, I., Quillet, R., Utard, V., Schmitt, M., Bourguignon, J.-J., Laboureyras, E., Ben Boujema, M., Simonnet, G., Ancel, C., Simonneaux, V., Beltramo, M., Bucher, B., Sorg, T., Meziane, H., Schneider, E., Petit-Demoulière, B., Ilien, B., Bihel, F.,* Simonin, F.* Neuropharmacology 118, 188–198. https://doi.org/10.1016/j.neuropharm.2017.03.012 - Discovery of Imidazoquinazolinone Derivatives as TSPO Ligands Modulating Neurosteroidogenesis and Cellular Bioenergetics in Neuroblastoma Cells Expressing Amyloid Precursor Protein.
Hallé, F., Lejri, I., Abarghaz, M., Grimm, A., Klein, C., Maitre, M., Schmitt, M., Bourguignon, J.-J., Mensah-Nyagan, A.G., Eckert, A.*, Bihel, F.*
ChemistrySelect 2, 6452–6457. https://doi.org/10.1002/slct.201701565 - The translocator protein ligand XBD173 improves clinical symptoms and neuropathological markers in the SJL/J mouse model of multiple sclerosis.
Leva, G., Klein, C., Benyounes, J., Hallé, F., Bihel, F., Collongues, N., Seze, J.D., Mensah-Nyagan, A.-G., Patte-Mensah, C.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/https://doi.org/10.1016/j.bbadis.2017.09.007 - Development of a L-Tryptophan-Based Ligand for Regioselective Copper Catalyzed N 2 -Arylation of 1,2,3-Triazoles.
Lopes, A.B., Wagner, P., Kümmerle, A.E., Bihel, F., Bourguignon, J.-J., Schmitt, M., Miranda, L.S.M. ChemistrySelect 2, 6544–6548. https://doi.org/10.1002/slct.201701498 - χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.
Van der Poorten, O., Van Den Hauwe, R., Eiselt, E., Betti, C., Guillemyn, K., Chung, N.N., Hallé, F., Bihel, F., Schiller, P.W., Tourwé, D., Sarret, P., Gendron, L., Ballet, S.,
ACS Medicinal Chemistry Letters 8, 1177–1182. https://doi.org/10.1021/acsmedchemlett.7b00347 - A phenol-enriched cuticle is ancestral to lignin evolution in land plants
Renault, H., Alber, A., Horst, N.A., Basilio Lopes, A., Fich, E.A., Kriegshauser, L., Wiedemann, G., Ullmann, P., Herrgott, L., Erhardt, M., Pineau, E., Ehlting, J., Schmitt, M., Rose, J.K.C., Reski, R., Werck-Reichhart, D.,
Nature Communications 8, 14713. https://doi.org/10.1038/ncomms14713
2016
- D-glucose : An efficient reducing agent for a Copper(II) mediated arylation of primary amines in water
Bollenbach M, Wagner P, Aquino P, Bourguignon J-J, Bihel F, Salomé C, and Schmitt M
ChemSusChem 2016, 9, 3244-3249 - RF-Amide Neuropeptides And Their Receptors In Mammals : Pharmacological Properties, Drug Development And Main Physiological Functions.
Quillet R, Ayachi S, Bihel F, Elhabazi K, Ilien B and Simonin F
Pharmacol Ther. 2016, 160, 84-132
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Opioid adjuvant strategy : improving opioid effectiveness
Bihel F
Future Med. Chem. 2016, 8, 339-354 - Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization
Hallé F., Van Der Poorten O., Doebelin C., Niederst M., Schneider S, Schmitt M., Ballet S., Bihel F.
Tetrahedron Letters 2016, 57, 1547-1550 -
The effect of Neuropeptide FF in the amygdala kindling model
Buffel I., Meurs A., Portelli J., Raedt R., De Herdt V., Poppe L., De Meulenaere V., Wadmann W., Bihel F., Schmitt M., Vonck K., Bourguignon J.J., Simonin F., Smolders I., Boon P.
Acta Neurologica Scandinavica 2016, 134, 181-188 -
CMTX disorder and CamKinase
Bihel F, Burkhard G, Fontes M
Front. Cell. Neurosci. 2016, 10 -
Development of Dipeptidic hGPR54 Agonists
C. Doebelin, I. Bertin, S. Schneider, M. Schmitt, J.-J. Bourguignon, C. Ancel, V. Simonneaux, F. Simonin, F. Bihel,
ChemMedChem 2016, 11, 2147-2154. - TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood
Marginedas-Freixa, I.;Hattab, C.;Bouyer, G.;Halle, F.;Chene, A.;Lefevre, S. D.;Cambot, M.;Cueff, A.;Schmitt, M.;Gamain, B.;Lacapere, J. J.;Egee, S.;Bihel, F.;Le Van Kim, C. and Ostuni, M. A.
Scientific Reports 2016, 6, 33516
2015
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Rapid and scalable synthesis of innovative unnatural α,β or γ-amino acids functionalized with tertiary amines on their side-chains.
Schneider S, Ftouni H, Niu S, Schmitt M, Simonin F, Bihel F.
Org Biomol Chem. 2015, 13(25), 7020-7026. - Development of a peptidomimetic antagonist of neuropeptide FF receptors for the prevention of opioid-induced hyperalgesia
Bihel, F.; Humbert, JP.; Schneider, S.; Bertin, I.; Wagner, P.; Schmitt, M.; Laboureyras, E.; Petit-Demoulière, B.; Schneider, E.; Mollereau, C.; Simonnet, G.; Simonin, F. and Bourguignon J.J.
ACS Chem Neuroscience 2015, 6(3), 438-45 -
Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.
Rouméas, L.; Humbert, J.-P.; Schneider, S.; Doebelin, C.; Bertin, I.; Schmitt, M.; Bourguignon, J.-J.; Simonin, F.; Bihel, F.
Peptides 2015, 71, 156-161. -
Neuropeptide FF receptors as novel targets for limbic seizure attenuation.
Portelli J, Meurs A, Bihel F, Hammoud H, Schmitt M, De Kock J, Utard V, Humbert JP, Bertin I, Buffel I, Coppens J, Tourwe D, Maes V, De Prins A, Vanhaecke T, Massie A, Balasubramaniam A, Boon P, Bourguignon JJ, Simonin F, Smolders I.
Neuropharmacology. 2015, 95, 415-423 -
Neuropeptide FF and prolactin releasing peptide decrease cortical excitability through activation of NPFF receptors
Buffel, I.; Meurs, A.; Portelli, J.; Raedt, R.; De Herdt, V.; Sioncke, L.; Wadman, W.; Bihel, F.; Schmitt, M.; Vonck, K.; Bourguignon, J.-J.; Simonin, F.; Smolders, I. and Boon, P.
Epilepsia 2015, 56(3), 489-98 -
The long-lasting love affair between the budding yeast Saccharomyces cerevisiae and the Epstein-Barr virus.
Lista, M. J.; Voisset, C.; Contesse, M.-A.; Friocourt, G.; Daskalogianni, C.; Bihel, F.; Fåhraeus, R.; Blondel, M.
Biotechnology Journal 2015, 16(11) 1670-1681 - Design and validation of a homogeneous time-resolved fluorescence cell-based assay targeting the ligand-gated ion channel 5-HT3A.
Blanc E, Wagner P, Plaisier F, Schmitt M, Durroux T, Bourguignon JJ, Partiseti M, Dupuis E, Bihel F.
Anal Biochem. 2015, 484, 105-112 -
A Yeast/Drosophila screen to identify new compounds overcoming frataxin deficiency
Seguin, A.; Monnier, V.; Palandri, A.; Bihel, F.; Rera, M.; Schmitt, M.; Camadro, J.-M.; Tricoire, H. and Lesuisse E.
Oxidative Medicine and Cellular Longevity 2015, 565140 -
CMTX1 patients' cells present genomic instability corrected by CamKII inhibitors
Mones, S.; Burkhardt, G.; Bordignon, B.; Altié, A.; Young, P.; Bihel, F.; Fraterno, M.; Peiretti, F.; Fontes, M.
Orphanet Journal of Rare Diseases 2015, 10, 56
2014
- Access to 4-Alkylaminopyridazine Derivatives via Nitrogen-Assisted Regioselective Pd-Catalyzed Reactions
Blaise, E.;Kümmerle, A. E.;Hammoud, H.;de Araújo-Júnior, J. X.;Bihel, F.;Bourguignon, J.-J. and Schmitt, M.
J Org Chem 2014, 79, 10311-10322 -
t-BuXPhos: a highly efficient ligand for Buchwald-Hartwig coupling in water.
Wagner, P.; Bollenbach, M.; Doebelin, C.; Bihel, F.; Bourguignon, J.-J.; Salome, C.; Schmitt, M.
Green Chem 2014, 16 (9), 4170-4178. - Structure-Activity Relationship Study around Guanabenz Identifies Two Derivatives Retaining Antiprion Activity but Having Lost alpha 2-Adrenergic Receptor Agonistic Activity
Nguyen, P. H.;Hammoud, H.;Halliez, S.;Pang, Y. H.;Evrard, J.;Schmitt, M.;Oumata, N.;Bourguignon, J. J.;Sanyal, S.;Beringue, V.;Blondel, M.;Bihel, F. and Voisset, C.
Acs Chemical Neuroscience 2014, 5, 1075-1082 -
Buchwald-Hartwig reactions in water using surfactants
Salome, C.; Wagner, P.; Bollenbach, M.; Bihel, F.; Bourguignon, J. J.; Schmitt, M.
Tetrahedron 2014, 70 (21), 3413-3421. -
CamKII inhibitors reduce mitotic instability, connexon anomalies andp rogression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene.
Mones, S.; Bordignon, B.; Peiretti, F.; Landrier, J. F.; Gess, B.; Bourguignon, J.-J.; Bihel, F.; Fontés, M.
Frontiers in Neuroscience 2014, 8, 1-10. -
Fully Regiocontrolled Polyarylation of Pyridine
Doebelin, C.; Wagner, P.; Bihel, F.; Humbert, N.; Kenfack, C. A.; Mely, Y.; Bourguignon, J. J.; Schmitt, M.
J Org Chem 2014, 79 (3), 908-918.
2013
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The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction
Klein, C.; Patte-Mensah, C.; Taleb, O.; Bourguignon, J. J.; Schmitt, M.; Bihel, F.; Maitre, M.; Mensah-Nyagan, A. G.
Neuropharmacology 2013, 70, 254-260. -
N-Heteroarylation of Chiral alpha-Aminoesters by Means of Palladium-Catalyzed Buchwald-Hartwig Reaction.
Hammoud, H.; Schmitt, M.; Blaise, E.; Bihel, F.; Bourguignon, J. J.
J Org Chem 2013, 78 (16), 7930-7937. -
Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors
Elhabazi, K.; Humbert, J. P.; Bertin, I.; Schmitt, M.; Bihel, F.; Bourguignon, J. J.; Bucher, B.; Becker, J. A. J.; Sorg, T.; Meziane, H.; Petit-Demouliere, B.; Ilien, B.; Simonin, F.
Neuropharmacology 2013, 75, 164-171. -
Synthesis and Antiproliferative Effects of 5,6-Disubstituted Pyridazin-3(2H)-ones Designed as Conformationally Constrained Combretastatin A-4 Analogues
Elagawany, M.; Schmitt, M.; Ghiaty, A.; El-Etrawy, A. S.; Ibrahim, M. A.; Bihel, F.; Sbardelotto, A. B.; Pessoa, C.; Nguyen, T. L.; Hamel, E.; Bourguignon, J. J.
Anti-Cancer Agents inMed Chem 2013, 13 (7), 1133-1140. -
Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists
Doebelin, C.; Wagner, P.; Bertin, I.; Simonin, F.; Schmitt, M.; Bihel, F.; Bourguignon, J. J.
Rsc Adv 2013, 3 (26), 10296-10300. -
Nucleophilic Substitution of Azide Acting as a Pseudo Leaving Group: One-Step Synthesis of Various Aza Heterocycles
Doebelin, C.; Schmitt, M.; Antheaume, C.; Bourguignon, J. J.; Bihel, F.
J Org Chem 2013, 78 (22), 11335-11341.
2012
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Direct Guanidinylation of Aryl and Heteroaryl Halides via Copper-Catalyzed Cross-Coupling Reaction
Hammoud, H.; Schmitt, M.; Bihel, F.; Antheaume, C.; Bourguignon, J. J.
J Org Chem 2012, 77 (1), 417-423 -
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors
Gealageas, R.; Schneider, S.; Humbert, J. P.; Bertin, I.; Schmitt, M.; Laboureyras, E.; Dugave, C.; Mollereau, C.; Simonnet, G.; Bourguignon, J. J.; Simonin, F.; Bihel, F.
Bioorg Med Chem Lett 2012, 22 (24), 7471-7474 -
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments
Elhabazi, K.; Trigo, J. M.; Mollereau, C.; Mouledous, L.; Zajac, J. M.; Bihel, F.; Schmitt, M.; Bourguignon, J. J.; Meziane, H.; Petit-demouliere, B.; Bockel, F.; Maldonado, R.; Simonin, F.
Brit J Pharmacol 2012, 165 (2), 424-435. -
Palladium-Catalyzed Synthesis of Substituted Pyrido[2,3-d]pyridazines at Positions 5 and 8
Ibrahim, M. A.; Blaise, E.; Lozach, O.; Szalata, C.; Schmitt, M.; El-Etrawy, A. A. S.; Elagawany, M.; El-Feky, S. A.; Abdel-Samii, Z. K.; Meijer, L.; Bourguignon, J. J.; Bihel, F.
Synthesis-Stuttgart 2012, 44 (20), 3216-3224. -
1-Phenyl-3H-2,3-benzodiazepin-4(5H)-one
Ballo, D.; Bihel, F.; Doubia, M. L.; Essassi, E. M.; Ng, S. W.
Acta Crystallographica Section E 2012, E68, o2443. -
Toward versatile methods leading to highly functionnalized imidazo [1,2-a]pyridines
Basilio-Lopes, A; De Aquino Mendonca, T; Mongeot, A; Bourguignon, JJ; Schmitt, M
Tetrahedron Lett 2012, 53(21), 2583-2587 -
Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors
Kummerle, AE; Schmitt, M; Cardozo, SVS; Lugnier, C; Villa, P; Lopes, AB; Romeiro, NC; Justiniano, H; Martins, MA; Fraga, CAM; Bourguignon, JJ; Barreiro, E.
J Med Chem 2012, 55(17), 7525-7545 -
Protein-protein and protein-membrane associations in the lignin pathway
Bassard, JE; Richert, L; Geerinck, J; Renault, H; Duval, F; Ullmann, P; Schmitt, M; Meyer, E; Mutterer, J; Boerjan, W; Werck, D.
Plant Cell 2012, 24(11), 4465-4482 -
Xanthurenic acid binds to neuronal G-protein-coupled receptors that secondarily activate cationic channels in the cell line NCB-20
Taleb, O; Maammar, M; Brumaru, D; Bourguignon, JJ; Schmitt, M; Klein, C; Kemmel, V; Maitre, M; Mensah-Nyagan, AG
PLoS One 2012, 7(11), e48553 -
Synthesis, sigma(1), sigma(2)-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes
Riganas, S; Papanastasiou, I; Foscolos, GB; Tsotinis, A; Bourguignon, JJ; Serin, G; Mirjolet, JF; Dimas, K; Kourafalos, VN; Eleutheriades, A; Moutsos, VI; Khan, H; Georgakopoulou, S; Zaniou, A; Prassa, M; Theodoropoulou, M; Pondiki, St; Vamvakides, A.
Bioorg Med Chem 2012, 20(10), 3323-3331 -
Novel access to 1,4-benzodiazepin-2-ones via the Buchwald reaction and application to the synthesis of novel heterocyclics
Salome, C; Schmitt, M; Bourguignon, JJ.
Tetrahedron Lett 2012, 53(9), 1033-1035 -
Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor
Keravis, T; Monneaux, F; Yougbare, I; Gazin, L; Bourguignon, JJ; Muller, S; Lugnier, C.
PLoS One 2012, 7(1), e28899
